| PPARD |
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| Наявні структури |
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| PDB | Пошук ортологів: PDBe RCSB |
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| Список кодів PDB | | 1GWX, 1Y0S, 2AWH, 2B50, 2BAW, 2ENV, 2GWX, 2J14, 2Q5G, 2XYJ, 2XYW, 2XYX, 2ZNP, 2ZNQ, 3D5F, 3DY6, 3ET2, 3GWX, 3GZ9, 3OZ0, 3PEQ, 3SP9, 3TKM | | |
| Ідентифікатори |
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| Символи | PPARD, FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB, peroxisome proliferator activated receptor delta |
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| Зовнішні ІД | OMIM: 600409 MGI: 101884 HomoloGene: 4544 GeneCards: PPARD |
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| Пов'язані генетичні захворювання |
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| цукровий діабет 2-го типу, diabetic cataract[1] |
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| Реагує на сполуку |
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| GW0742X, GW-501516, третиноїн, elafibranor, sodelglitazar, indeglitazar[2] |
| Онтологія гена |
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| Молекулярна функція | • sequence-specific DNA binding
• GO:0001105 transcription coactivator activity
• zinc ion binding
• зв'язування з іоном металу
• steroid hormone receptor activity
• fatty acid binding
• GO:0001948, GO:0016582 protein binding
• linoleic acid binding
• protein heterodimerization activity
• lipid binding
• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
• transcription factor binding
• GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity
• DNA binding
• GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
• NF-kappaB binding
• GO:0000975 transcription cis-regulatory region binding
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• nuclear receptor coactivator activity
• signaling receptor activity
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| Клітинна компонента | • нуклеоплазма
• клітинне ядро
• RNA polymerase II transcription regulator complex
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| Біологічний процес | • fatty acid catabolic process
• positive regulation of myoblast proliferation
• positive regulation of epidermis development
• диференціація клітин
• negative regulation of smooth muscle cell proliferation
• negative regulation of myoblast differentiation
• GO:0009373 regulation of transcription, DNA-templated
• placenta development
• GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
• negative regulation of smooth muscle cell migration
• Загоєння ран
• mRNA transcription
• cholesterol metabolic process
• negative regulation of apoptotic process
• response to glucose
• response to activity
• response to organic substance
• generation of precursor metabolites and energy
• regulation of fat cell differentiation
• transcription, DNA-templated
• GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
• response to vitamin A
• heart development
• cell-substrate adhesion
• keratinocyte proliferation
• GO:1901313 positive regulation of gene expression
• proteoglycan metabolic process
• regulation of cell population proliferation
• negative regulation of cell growth
• fatty acid oxidation
• positive regulation of cell population proliferation
• glucose metabolic process
• phospholipid biosynthetic process
• negative regulation of epithelial cell proliferation
• positive regulation of skeletal muscle tissue regeneration
• apoptotic signaling pathway
• vitamin A metabolic process
• positive regulation of phosphatidylinositol 3-kinase signaling
• keratinocyte migration
• adipose tissue development
• transcription initiation from RNA polymerase II promoter
• regulation of skeletal muscle satellite cell proliferation
• positive regulation of fat cell differentiation
• GO:0045996 negative regulation of transcription, DNA-templated
• negative regulation of inflammatory response
• cellular response to lipopolysaccharide
• cellular response to hypoxia
• negative regulation of collagen biosynthetic process
• positive regulation of insulin secretion
• steroid hormone mediated signaling pathway
• GO:0097285 апоптоз
• проліферація
• GO:1901227 negative regulation of transcription by RNA polymerase II
• intracellular receptor signaling pathway
• axon ensheathment
• decidualization
• fatty acid transport
• embryo implantation
• negative regulation of pri-miRNA transcription by RNA polymerase II
• lipid metabolism
• fatty acid beta-oxidation
• glucose transmembrane transport
• fatty acid metabolic process
• multicellular organism development
• hormone-mediated signaling pathway
• negative regulation of cholesterol storage
• regulation of lipid metabolic process
• response to lipid
• GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
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| Джерела:Amigo / QuickGO | |
| Шаблон експресії |
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| Більше даних |
| Ортологи |
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| Види | Людина | Миша |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (мРНК) | | NM_001171818
NM_001171819
NM_001171820
NM_006238
NM_177435 |
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| RefSeq (білок) | | NP_001165289
NP_001165290
NP_001165291
NP_006229
NP_803184 |
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| Локус (UCSC) | Хр. 6: 35.34 – 35.43 Mb | Хр. 17: 28.23 – 28.3 Mb |
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| PubMed search | [3] | [4] |
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| Вікідані |
| Див./Ред. для людей | Див./Ред. для мишей |
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