DEDD

DEDD
識別號
别名DEDD；, CASP8IP1, DEDD1, DEFT, FLDED1, KE05, death effector domain containing
外部IDOMIM：606841 MGI：1333874 HomoloGene：7980 GeneCards：DEDD
基因位置（人类）
1號染色體
染色体1號染色體[1]
1號染色體
DEDD的基因位置
DEDD的基因位置
基因座1q23.3起始161,120,974 bp[1]
终止161,132,688 bp[1]
基因位置（小鼠）
小鼠1号染色体
染色体小鼠1号染色体[2]
小鼠1号染色体
DEDD的基因位置
DEDD的基因位置
基因座1 H3|1 79.34 cM起始171,156,713 bp[2]
终止171,169,899 bp[2]
RNA表达模式




查阅更多表达数据
基因本體
分子功能• 血浆蛋白结合
• DNA结合
細胞組分• 細胞質
• 细胞核
• 核仁
生物學過程• regulation of apoptotic process
• regulation of transcription, DNA-templated
• transcription, DNA-templated
• 细胞凋亡
• 精子发生
• extrinsic apoptotic signaling pathway via death domain receptors
• negative regulation of protein catabolic process
• 蛻膜化
• negative regulation of transcription of nucleolar large rRNA by RNA polymerase I
Sources:Amigo / QuickGO
直系同源
物種人類小鼠
Entrez

9191

21945

Ensembl

ENSG00000158796

ENSMUSG00000013973

UniProt

O75618

Q9Z1L3

mRNA​序列

​NM_001039711
​NM_001039712
​NM_004216
​NM_032998
​NM_001330765

NM_001128609
​NM_011615
​NM_001357550
​NM_001357551
​NM_001357552

​NM_001357553

蛋白序列

NP_001034800
​NP_001034801
​NP_001317694
​NP_127491

NP_001122081
​NP_035745
​NP_001344479
​NP_001344480
​NP_001344481

​NP_001344482

基因位置​（UCSC）Chr 1: 161.12 – 161.13 MbChr 1: 171.16 – 171.17 Mb
PubMed​查找[3][4]
維基數據
檢視/編輯人類檢視/編輯小鼠

含死亡效应结构域蛋白（英語：Death effector domain containing protein）是人类中由DEDD基因编码的蛋白质。[5][6][7]

功能

该基因编码含有死亡效应结构域（DED）的蛋白质。DED是程序性细胞死亡途径的衔接子、调节子和执行子共享的蛋白质相互作用域。该基因的过度表达被证明可诱导微弱的细胞凋亡。在刺激作用下，发现该蛋白从细胞质易位到细胞核，并与UBTF共定位在核仁中，UBTF是RNA聚合酶I转录所需的基础因子。该基因至少有三种编码相同蛋白质的转录变体。[8]

相互作用

DEDD已被证明可以与以下基因产生相互作用：

参考资料

  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000158796 - Ensembl, May 2017
  2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000013973 - Ensembl, May 2017
  3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ 5.0 5.1 Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhänsel C, Hofmann TG, Grummt I, Krammer PH, Peter ME. DEDD, a novel death effector domain-containing protein, targeted to the nucleolus. EMBO J. Dec 1998, 17 (20): 5974–86. PMC 1170924 可免费查阅. PMID 9774341. doi:10.1093/emboj/17.20.5974. 
  6. ^ Leo CP, Hsu SY, McGee EA, Salanova M, Hsueh AJ. DEFT, a novel death effector domain-containing molecule predominantly expressed in testicular germ cells. Endocrinology. Dec 1998, 139 (12): 4839–48. PMID 9832420. doi:10.1210/endo.139.12.6335 可免费查阅. 
  7. ^ Entrez Gene: DEDD death effector domain containing. [2024-03-15]. （原始内容存档于2010-12-05）. 
  8. ^ 引用错误：没有为名为entrez2的参考文献提供内容
  9. ^ 9.0 9.1 Zhan Y, Hegde R, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES. Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC. Cell Death Differ. Apr 2002, 9 (4): 439–47. PMID 11965497. doi:10.1038/sj.cdd.4401038 可免费查阅. 
  10. ^ 10.0 10.1 Roth W, Stenner-Liewen F, Pawlowski K, Godzik A, Reed JC. Identification and characterization of DEDD2, a death effector domain-containing protein. J. Biol. Chem. Mar 2002, 277 (9): 7501–8. PMID 11741985. doi:10.1074/jbc.M110749200 可免费查阅. 
  11. ^ Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhänsel C, Hofmann TG, Grummt I, Krammer PH, Peter ME. DEDD, a novel death effector domain-containing protein, targeted to the nucleolus. EMBO J. Oct 1998, 17 (20): 5974–86. PMC 1170924 可免费查阅. PMID 9774341. doi:10.1093/emboj/17.20.5974. 
  12. ^ Alcivar A, Hu S, Tang J, Yang X. DEDD and DEDD2 associate with caspase-8/10 and signal cell death. Oncogene. Jan 2003, 22 (2): 291–7. PMID 12527898. doi:10.1038/sj.onc.1206099 可免费查阅. 

延伸阅读

  • Park MY, Ryu SW, Kim KD, Lim JS, Lee ZW, Kim E. Fas-associated factor-1 mediates chemotherapeutic-induced apoptosis via death effector filament formation. Int. J. Cancer. 2005, 115 (3): 412–8. PMID 15688372. doi:10.1002/ijc.20857 可免费查阅. 
  • Alcivar A, Hu S, Tang J, Yang X. DEDD and DEDD2 associate with caspase-8/10 and signal cell death. Oncogene. 2003, 22 (2): 291–7. PMID 12527898. doi:10.1038/sj.onc.1206099 可免费查阅. 
  • Lee JC, Schickling O, Stegh AH, Oshima RG, Dinsdale D, Cohen GM, Peter ME. DEDD regulates degradation of intermediate filaments during apoptosis. J. Cell Biol. 2002, 158 (6): 1051–66. PMC 2173221 可免费查阅. PMID 12235123. doi:10.1083/jcb.200112124. 
  • Zhan Y, Hegde R, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES. Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC. Cell Death Differ. 2002, 9 (4): 439–47. PMID 11965497. doi:10.1038/sj.cdd.4401038 可免费查阅. 
  • Schickling O, Stegh AH, Byrd J, Peter ME. Nuclear localization of DEDD leads to caspase-6 activation through its death effector domain and inhibition of RNA polymerase I dependent transcription. Cell Death Differ. 2002, 8 (12): 1157–68. PMID 11753564. doi:10.1038/sj.cdd.4400928 可免费查阅. 
  • Roth W, Stenner-Liewen F, Pawlowski K, Godzik A, Reed JC. Identification and characterization of DEDD2, a death effector domain-containing protein. J. Biol. Chem. 2002, 277 (9): 7501–8. PMID 11741985. doi:10.1074/jbc.M110749200 可免费查阅.