Tromboksan-A sintaza

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Tromboksan A sintaza 1 (trombocitna)
Identifikatori
SimboliTBXAS1; BDPLT14; CYP5; CYP5A1; GHOSAL; THAS; TS; TXAS; TXS
Vanjski IDOMIM: 274180 MGI: 98497 HomoloGene: 55549 GeneCards: TBXAS1 Gene
EC broj5.3.99.5
Ontologija gena
Molekularna funkcija • aktivnost monooksigenaze
• aktivnost tromboksan-A sintaze
• vezivanje jona gvožđa
• aktivnost nosača elektrona
Celularna komponenta • membrana endoplazmičnog retikuluma
• integralno sa membranom
Biološki proces • proces prostaglandinske biosinteze
• proces eikozanoidnog metabolizma
• proces ksenobiotičkog metabolizma
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez691621391
EnsemblENSG00000059377ENSMUSG00000029925
UniProtP24557P36423
RefSeq (mRNA)NM_001061.4NM_011539.3
RefSeq (protein)NP_001052.2NP_035669.3
Lokacija (UCSC)Chr 7:
139.48 - 139.72 Mb		Chr 6:
38.88 - 39.08 Mb
PubMed pretraga[1][2]

Tromboksan-A sintaza 1 (EC 5.3.99.5, trombocit, citohrom P450, familija 5, potfamilija A), takođe poznata kao TBXAS1, je enzim koji je kod ljudi kodiran TBXAS1 genom.[1][2][3]

Reference

  1. ↑ „Entrez Gene: TBXAS1 thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A)”. 
  2. ↑ Yokoyama C, Miyata A, Ihara H, Ullrich V, Tanabe T (August 1991). „Molecular cloning of human platelet thromboxane A synthase”. Biochem. Biophys. Res. Commun. 178 (3): 1479–1484. DOI:10.1016/0006-291X(91)91060-P. PMID 1714723. 
  3. ↑ Baek SJ, Lee KD, Shen RF (September 1996). „Genomic structure and polymorphism of the human thromboxane synthase-encoding gene”. Gene 173 (2): 251–256. DOI:10.1016/0378-1119(95)00881-0. PMID 8964509. 

Literatura

  • Shen RF, Tai HH (1998). „Thromboxanes: synthase and receptors”. J. Biomed. Sci. 5 (3): 153–172. DOI:10.1007/BF02253465. PMID 9678486. 
  • Smith G, Stubbins MJ, Harries LW, Wolf CR (1999). „Molecular genetics of the human cytochrome P450 monooxygenase superfamily”. Xenobiotica 28 (12): 1129–1165. DOI:10.1080/004982598238868. PMID 9890157. 
  • Wang LH, Kulmacz RJ (2003). „Thromboxane synthase: structure and function of protein and gene”. Prostaglandins Other Lipid Mediat. 68-69: 409–422. DOI:10.1016/S0090-6980(02)00045-X. PMID 12432933. 
  • Itoh S, Yanagimoto T, Tagawa S i dr.. (1992). „Genomic organization of human fetal specific P-450IIIA7 (cytochrome P-450HFLa)-related gene(s) and interaction of transcriptional regulatory factor with its DNA element in the 5' flanking region”. Biochim. Biophys. Acta 1130 (2): 133–8. PMID 1562592. 
  • Yokoyama C, Miyata A, Ihara H i dr.. (1991). „Molecular cloning of human platelet thromboxane A synthase”. Biochem. Biophys. Res. Commun. 178 (3): 1479–1484. DOI:10.1016/0006-291X(91)91060-P. PMID 1714723. 
  • Ohashi K, Ruan KH, Kulmacz RJ i dr.. (1992). „Primary structure of human thromboxane synthase determined from the cDNA sequence”. J. Biol. Chem. 267 (2): 789–93. PMID 1730669. 
  • Jones DA, Fitzpatrick FA, Malcolm KC (1991). „Thromboxane A2 synthesis in human erythroleukemia cells”. Biochem. Biophys. Res. Commun. 180 (1): 8–14. DOI:10.1016/S0006-291X(05)81247-1. PMID 1930241. 
  • Wang LH, Ohashi K, Wu KK (1991). „Isolation of partial complementary DNA encoding human thromboxane synthase”. Biochem. Biophys. Res. Commun. 177 (1): 286–291. DOI:10.1016/0006-291X(91)91980-Q. PMID 2043115. 
  • Nüsing R, Schneider-Voss S, Ullrich V (1990). „Immunoaffinity purification of human thromboxane synthase”. Arch. Biochem. Biophys. 280 (2): 325–330. DOI:10.1016/0003-9861(90)90337-X. PMID 2195994. 
  • Mestel F, Oetliker O, Beck E i dr.. (1980). „Severe bleeding associated with defective thromboxane synthetase”. Lancet 1 (8160): 157. DOI:10.1016/S0140-6736(80)90642-X. PMID 6101498. 
  • Miyata A, Yokoyama C, Ihara H i dr.. (1994). „Characterization of the human gene (TBXAS1) encoding thromboxane synthase”. Eur. J. Biochem. 224 (2): 273–279. DOI:10.1111/j.1432-1033.1994.00273.x. PMID 7925341. 
  • Wang LH, Tazawa R, Lang AQ, Wu KK (1995). „Alternate splicing of human thromboxane synthase mRNA”. Arch. Biochem. Biophys. 315 (2): 273–278. DOI:10.1006/abbi.1994.1500. PMID 7986068. 
  • Maruyama K, Sugano S (1994). „Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene 138 (1–2): 171–174. DOI:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Lee KD, Baek SJ, Shen RF (1994). „Cloning and characterization of the human thromboxane synthase gene promoter”. Biochem. Biophys. Res. Commun. 201 (1): 379–387. DOI:10.1006/bbrc.1994.1712. PMID 8198598. 
  • Chase MB, Baek SJ, Purtell DC i dr.. (1993). „Mapping of the human thromboxane synthase gene (TBXAS1) to chromosome 7q34-q35 by two-color fluorescence in situ hybridization”. Genomics 16 (3): 771–773. DOI:10.1006/geno.1993.1264. PMID 8325653. 
  • Ruan KH, Wang LH, Wu KK, Kulmacz RJ (1993). „Amino-terminal topology of thromboxane synthase in the endoplasmic reticulum”. J. Biol. Chem. 268 (26): 19483–90. PMID 8366093. 
  • Tazawa R, Green ED, Ohashi K i dr.. (1996). „Characterization of the complete genomic structure of human thromboxane synthase gene and functional analysis of its promoter”. Arch. Biochem. Biophys. 334 (2): 349–356. DOI:10.1006/abbi.1996.0464. PMID 8900410. 
  • Baek SJ, Lee KD, Shen RF (1996). „Genomic structure and polymorphism of the human thromboxane synthase-encoding gene”. Gene 173 (2): 251–256. DOI:10.1016/0378-1119(95)00881-0. PMID 8964509. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K i dr.. (1997). „Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library”. Gene 200 (1–2): 149–156. DOI:10.1016/S0378-1119(97)00411-3. PMID 9373149. 

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Spoljašnje veze

  • MeSH Thromboxane-A+Synthase
  • p
  • r
  • u
TemeTipovi
EC1 Oksidoreduktaze/spisak  • EC2 Transferaze/spisak  • EC3 Hidrolaze/spisak  • EC4 Lijaze/spisak  • EC5 Izomeraze/spisak  • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6