Receptor 1 faktora stimulacije kolonija

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Receptor 1 faktora stimulacije kolonija

Prikaz baziran na PDB 2I0V.
Dostupne strukture
2I0V, 2I0Y, 2I1M, 2OGV, 3BEA, 3DPK, 3KRJ, 3KRL, 3LCD, 3LCO, 4DKD, 4HW7
Identifikatori
SimboliCSF1R; C-FMS; CD115; CSF-1R; CSFR; FIM2; FMS; HDLS; M-CSF-R
Vanjski IDOMIM: 164770 MGI: 1339758 HomoloGene: 3817 GeneCards: CSF1R Gene
EC broj2.7.10.1
Ontologija gena
Molekulska funkcija aktivnost receptora faktora stimulacije makrofagne kolonije
ATP vezivanje
vezivanje proteinske fosfataze
Ćelijska komponenta ćelijska membrana
integralna komponenta ćelijske membrane
ćelijska površina
Biološki proces pozitivna regulacija proteinske fosforilacije
inflamatorni respons
prenos signala
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez143612978
EnsemblENSG00000182578ENSMUSG00000024621
UniProtP07333P09581
Ref. Sekv. (iRNK)NM_001288705NM_001037859
Ref. Sekv. (protein)NP_001275634NP_001032948
Lokacija (UCSC)Chr 5:
149.43 - 149.49 Mb
Chr 18:
61.11 - 61.13 Mb
PubMed pretraga[1][2]

Receptor 1 faktora stimulacije kolonija (CSF1R, receptor faktora stimulacije makrofagnih kolonija, M-CSFR, CD115, Klaster Diferencijacije 115), je protein sa ćelijske površine koji je kod ljudi kodiran CSF1R genom.[1][2] On je receptor za citokin sa imenom faktor stimulacije kolonija 1.

Interakcije

Ovaj receptor formira interakcije sa:

  • Cbl gen,[3]
  • FYN,[4]
  • Grb2,[5]
  • Supresor citokinske signalizacije 1,[6]

Vidi još

  • Klaster diferencijacije

Reference

  1. EntrezGene 1436
  2. Galland F, Stefanova M, Lafage M, Birnbaum D (1992). „Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15→q23”. Cytogenet. Cell Genet. 60 (2): 114–6. DOI:10.1159/000133316. PMID 1611909. 
  3. Mancini A, Koch A, Wilms R, Tamura T (April 2002). „c-Cbl associates directly with the C-terminal tail of the receptor for the macrophage colony-stimulating factor, c-Fms, and down-modulates this receptor but not the viral oncogene v-Fms”. J. Biol. Chem. 277 (17): 14635–40. DOI:10.1074/jbc.M109214200. PMID 11847211. 
  4. Courtneidge SA, Dhand R, Pilat D, Twamley GM, Waterfield MD, Roussel MF (March 1993). „Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor”. EMBO J. 12 (3): 943–50. PMC 413295. PMID 7681396. 
  5. Mancini A, Niedenthal R, Joos H, Koch A, Trouliaris S, Niemann H, Tamura T (September 1997). „Identification of a second Grb2 binding site in the v-Fms tyrosine kinase”. Oncogene 15 (13): 1565–72. DOI:10.1038/sj.onc.1201518. PMID 9380408. 
  6. Bourette RP, De Sepulveda P, Arnaud S, Dubreuil P, Rottapel R, Mouchiroud G (June 2001). „Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal”. J. Biol. Chem. 276 (25): 22133–9. DOI:10.1074/jbc.M101878200. PMID 11297560. 

Literatura

  • Rettenmier CW, Roussel MF, Sherr CJ (1988). „The colony-stimulating factor 1 (CSF-1) receptor (c-fms proto-oncogene product) and its ligand”. J. Cell Sci. Suppl. 9: 27–44. PMID 2978516. 
  • Stanley ER, Berg KL, Einstein DB, Lee PS, Pixley FJ, Wang Y, Yeung YG (January 1997). „Biology and action of colony--stimulating factor-1”. Mol. Reprod. Dev. 46 (1): 4–10. DOI:10.1002/(SICI)1098-2795(199701)46:1<4::AID-MRD2>3.0.CO;2-V. PMID 8981357. 
  • Gout I, Dhand R, Panayotou G, Fry MJ, Hiles I, Otsu M, Waterfield MD (December 1992). „Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system”. Biochem. J. 288 ( Pt 2): 395–405. PMC 1132024. PMID 1334406. 
  • Boultwood J, Rack K, Kelly S, Madden J, Sakaguchi AY, Wang LM, Oscier DG, Buckle VJ, Wainscoat JS (July 1991). „Loss of both CSF1R (FMS) alleles in patients with myelodysplasia and a chromosome 5 deletion”. Proc. Natl. Acad. Sci. U.S.A. 88 (14): 6176–80. DOI:10.1073/pnas.88.14.6176. PMC 52045. PMID 1829836. 
  • Roussel MF, Cleveland JL, Shurtleff SA, Sherr CJ (September 1991). „Myc rescue of a mutant CSF-1 receptor impaired in mitogenic signalling”. Nature 353 (6342): 361–3. DOI:10.1038/353361a0. PMID 1833648. 
  • Reedijk M, Liu XQ, Pawson T (November 1990). „Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor”. Mol. Cell. Biol. 10 (11): 5601–8. PMC 361316. PMID 2172781. 
  • Sherr CJ, Rettenmier CW, Sacca R, Roussel MF, Look AT, Stanley ER (July 1985). „The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1”. Cell 41 (3): 665–76. DOI:10.1016/S0092-8674(85)80047-7. PMID 2408759. 
  • Coussens L, Van Beveren C, Smith D, Chen E, Mitchell RL, Isacke CM, Verma IM, Ullrich A (1986). „Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus”. Nature 320 (6059): 277–80. DOI:10.1038/320277a0. PMID 2421165. 
  • Hampe A, Shamoon BM, Gobet M, Sherr CJ, Galibert F (1989). „Nucleotide sequence and structural organization of the human FMS proto-oncogene”. Oncogene Res. 4 (1): 9–17. PMID 2524025. 
  • Visvader J, Verma IM (March 1989). „Differential transcription of exon 1 of the human c-fms gene in placental trophoblasts and monocytes”. Mol. Cell. Biol. 9 (3): 1336–41. PMC 362728. PMID 2524648. 
  • Roberts WM, Look AT, Roussel MF, Sherr CJ (November 1988). „Tandem linkage of human CSF-1 receptor (c-fms) and PDGF receptor genes”. Cell 55 (4): 655–61. DOI:10.1016/0092-8674(88)90224-3. PMID 2846185. 
  • Xu DQ, Guilhot S, Galibert F (May 1985). „Restriction fragment length polymorphism of the human c-fms gene”. Proc. Natl. Acad. Sci. U.S.A. 82 (9): 2862–5. DOI:10.1073/pnas.82.9.2862. JSTOR 25278. PMC 397666. PMID 2986142. 
  • Sherr CJ, Rettenmier CW (1986). „The fms gene and the CSF-1 receptor”. Cancer Surv. 5 (2): 221–32. PMID 3022923. 
  • Le Beau MM, Westbrook CA, Diaz MO, Larson RA, Rowley JD, Gasson JC, Golde DW, Sherr CJ (February 1986). „Evidence for the involvement of GM-CSF and FMS in the deletion (5q) in myeloid disorders”. Science 231 (4741): 984–7. DOI:10.1126/science.3484837. PMID 3484837. 
  • Wheeler EF, Roussel MF, Hampe A, Walker MH, Fried VA, Look AT, Rettenmier CW, Sherr CJ (August 1986). „The amino-terminal domain of the v-fms oncogene product includes a functional signal peptide that directs synthesis of a transforming glycoprotein in the absence of feline leukemia virus gag sequences”. J. Virol. 59 (2): 224–33. PMC 253070. PMID 3525854. 
  • Verbeek JS, Roebroek AJ, van den Ouweland AM, Bloemers HP, Van de Ven WJ (February 1985). „Human c-fms proto-oncogene: comparative analysis with an abnormal allele”. Mol. Cell. Biol. 5 (2): 422–6. PMC 366728. PMID 3974576. 
  • Lee AW, Nienhuis AW (September 1990). „Mechanism of kinase activation in the receptor for colony-stimulating factor 1”. Proc. Natl. Acad. Sci. U.S.A. 87 (18): 7270–4. DOI:10.1073/pnas.87.18.7270. PMC 54725. PMID 2169623. 

Vanjske veze

  • MeSH CSF1R+protein,+human
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Receptori faktora rasta
EGFR • ERBB2 • ERBB3 • ERBB4
IGF1R • INSR • INSRR
CSF1R • FLT3 • KIT • PDGFR (PDGFRA, PDGFRB)
FGFR1 • FGFR2 • FGFR3 • FGFR4
VEGFR1 • VEGFR2 • VEGFR3 • VEGFR4
MET • RON
NTRK1 • NTRK2 • NTRK3
EPH receptorska familija
EPHA1 • EPHA2 • EPHA3 • EPHA4 • EPHA5 • EPHA6 • EPHA7 • EPHA8 • EPHB1 • EPHB2 • EPHB3 • EPHB4 • EPHB5 • EPHB6 • EPHX
LTK receptorska familija
LTK • ALK
TIE receptorska familija
TIE • TEK
ROR receptorska familija
ROR1 • ROR2
DDR receptorska familija
DDR1 • DDR2
PTK7 receptorska familija
RYK receptorska familija
MuSK receptorska familija
ROS receptorska familija
ROS1
AATYK receptorska familija
AATYK • AATYK2 • AATYK3
AXL receptorska familija
AXL • MER • TYRO3
RET receptorska familija
nekategorisani
  • p
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ABL familija
ABL1 • ARG
ACK familija
ACK1 • TNK1
CSK familija
CSK • MATK
FAK familija
FAK • PYK2
FES familija
FES • FER
FRK familija
FRK • BRK • SRMS
JAK familija
JAK1 • JAK2 • JAK3 • TYK2
SRC-A familija
SRC • FGR • FYN • YES1
SRC-B familija
BLK • HCK • LCK • LYN
TEC familija
TEC • BMX • BTK • ITK • TXK
SYK familija
SYK • ZAP70
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
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1-50
CD1 (a-c, 1A, 1D, 1E) • CD2 • CD3 (γ, δ, ε) • CD4 • CD5 • CD6 • CD7 • CD8 (a) • CD9 • CD10 • CD11 (a, b, c) • CD13 • CD14 • CD15 • CD16 (A, B) • CD18 • CD19 • CD20 • CD21 • CD22 • CD23 • CD24 • CD25 • CD26 • CD27 • CD28 • CD29 • CD30 • CD31 • CD32 (A, B) • CD33 • CD34 • CD35 • CD36 • CD37 • CD38 • CD39 • CD40 • CD41 • CD42 (a, b, c, d) • CD43 • CD44 • CD45 • CD46 • CD47 • CD48 • CD49 (a, b, c, d, e, f) • CD50
51-100
CD51 • CD52 • CD53 • CD54 • CD55 • CD56 • CD57 • CD58 • CD59 • CD61 • CD62 (E, L, P) • CD63 • CD64 (A, B, C) • CD66 (a, b, c, d, e, f) • CD68 • CD69 • CD70 • CD71 • CD72 • CD73 • CD74 • CD78 • CD79 (a, b) • CD80 • CD81 • CD82 • CD83 • CD84 • CD85 (a, d, e, h, j, k) • CD86 • CD87 • CD88 • CD89 • CD90 • CD91- CD92 • CD93 • CD94 • CD95 • CD96 • CD97 • CD98 • CD99 • CD100
101-150
CD101 • CD102 • CD103 • CD104 • CD105 • CD106 • CD107 (a, b) • CD108 • CD109 • CD110 • CD111 • CD112 • CD113 • CD114 • CD115 • CD116 • CD117 • CD118 • CD119 • CD120 (a, b) • CD121 (a, b) • CD122 • CD123 • CD124 • CD125 • CD126 • CD127 • CD129 • CD130 • CD131 • CD132 • CD133 • CD134 • CD135 • CD136 • CD137 • CD138 • CD140b • CD141 • CD142 • CD143 • CD144 • CD146 • CD147 • CD148 • CD150
151-200
CD151 • CD152 • CD153 • CD154 • CD155 • CD156 (a, b, c) • CD157 • CD158 (a, d, e, i, k) • CD159 (a, c) • CD160 • CD161 • CD162 • CD163 • CD164 • CD166 • CD167 (a, b) • CD168 • CD169 • CD170 • CD171 • CD172 (a, b, g) • CD174 • CD177 • CD178 • CD179 (a, b) • CD181 • CD182 • CD183 • CD184 • CD185 • CD186 • CD191 • CD192 • CD193 • CD194 • CD195 • CD196 • CD197 • CDw198 • CDw199 • CD200
201-250
CD201 • CD202b • CD204 • CD205 • CD206 • CD207 • CD208 • CD209 • CDw210 (a, b) • CD212 • CD213a (1, 2) • CD217 • CD218 (a, b) • CD220 • CD221 • CD222 • CD223 • CD224 • CD225 • CD226 • CD227 • CD228 • CD229 • CD230 • CD233 • CD234 • CD235 (a, b) • CD236 • CD238 • CD239 • CD240CE • CD241 • CD243 • CD244 • CD246 • CD247- CD248 • CD249
251-300
CD252 • CD253 • CD254 • CD256 • CD257 • CD258 • CD261 • CD262 • CD264 • CD265 • CD266 • CD267 • CD268 • CD269 • CD271 • CD272 • CD273 • CD274 • CD275 • CD276 • CD278 • CD279 • CD280 • CD281 • CD282 • CD283 • CD284 • CD286 • CD288 • CD289 • CD290 • CD292 • CDw293 • CD294 • CD295 • CD297 • CD298 • CD299
301-350
CD300A • CD301 • CD302 • CD303 • CD304 • CD305 • CD306 • CD307 • CD309 • CD312 • CD314 • CD315 • CD316 • CD317 • CD318 • CD320 • CD321 • CD322 • CD324 • CD325 • CD326 • CD328 • CD329 • CD331 • CD332 • CD333 • CD334 • CD335 • CD336 • CD337 • CD338 • CD339 • CD340 • CD344 • CD349 • CD350
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Hemokinski receptor
(GPCR)
CC hemokinski receptori
CCR1  CCRL1  CCR2  CCRL2  CCR3  CCR4  CCR5  CCR6  CCR7  CCR8  CCR9  CCR10
CXC hemokinski receptori
IL-8 (CXCR1, CXCR2)  CXCR3  CXCR4  CXCR5  CXCR6  CXCR7
Drugi
CCBP2  CMKLR1  CX3CR1  XCR1
TNF receptor
1-10
TNFRSF1 (CD120)  TNFRSF1A (CD120a)  TNFRSF1B (CD120b)  TNFRSF3 (Limfotoksin beta receptor)  TNFRSF4 (CD134)  TNFRSF5 (CD40)  TNFRSF6 (FAS)  TNFRSF6B  TNFRSF7 (CD27)  TNFRSF8 (CD30)  TNFRSF9 (CD137)
11-20
TNFRSF10A (CD261)  TNFRSF10B (CD262)  TNFRSF10C (CD263)  TNFRSF10D (CD264)  TNFRSF11A (CD265/RANK)  TNFRSF11B (Osteoprotegerin)  TNFRSF12A (CD266)  TNFRSF13B (CD267)  TNFRSF13C  TNFRSF14 (CD268)  TNFRSF16 (Receptor nervnog faktora rasta)  TNFRSF17 (CD269)  TNFRSF18  TNFRSF19
21-25
TNFRSF21  TNFRSF25  TNFRSF27
JAK-STAT
zajednički beta lanac: Interleukinski receptori (3, 5)  GM-CSF

zajednički gama lanac: Interleukinski receptori (2, 4, 7, 9, 13/A1/A2, 15, 21)

gp130 koristeći: Interleukinski receptori (6, 27)  Onkostatin M  Leukemija inhibitorni faktor

drugi Interleukinski receptori (11/A, 12/B1/B2, 23)

drugi CSF receptori (EPO, G-CSF, Trombopoietin)

Hormonski receptor: GH  prolaktin
Tip II
Interleukini (10, 20, 22, 28)  interferon (-α/β, -γ)
Ig superfamilija
CSF1  C-kit  IL-1 (IL1R1, IL1R2)  IL-18
S/T
TGF-beta (1, 2)
Drugi
IL-17 (IL17RA, IL17RB, IL17RC, IL17RD, IL17RE)
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)