RGS6
| edit |
| Regulator G-proteinske signalizacije 6 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 PDB prikaz baziran na 2es0. | |||||||||||
| Dostupne strukture | |||||||||||
| 2ES0 | |||||||||||
| Identifikatori | |||||||||||
| Simboli | RGS6; GAP | ||||||||||
| Vanjski ID | OMIM: 603894 MGI: 1354730 HomoloGene: 68385 GeneCards: RGS6 Gene | ||||||||||
| |||||||||||
| Pregled RNK izražavanja | |||||||||||
 | |||||||||||
 | |||||||||||
 | |||||||||||
| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 9628 | 50779 | |||||||||
| Ensembl | ENSG00000182732 | ENSMUSG00000021219 | |||||||||
| UniProt | P49758 | Q9Z2H2 | |||||||||
| Ref. Sekv. (iRNK) | NM_001204416 | NM_001282061 | |||||||||
| Ref. Sekv. (protein) | NP_001191345 | NP_001268990 | |||||||||
| Lokacija (UCSC) | Chr 14: 72.4 - 73.03 Mb | Chr 12: 82.62 - 83.13 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Regulator G-proteinske signalizacije 6 je protein koji je kod ljudi kodiran RGS6 genom.[1][2][3]
Članovi RGS familije (regulatori G proteinske signalizacije) modulišu dejstvo G proteina putem aktivacije GTPaznih alfa podjedinica (koje vezuju nukleotid guanin).[3]
Interactions
RGS6 formira interakcije sa STMN2[4] and DMAP1.[2]
Reference
- ↑ Seki N, Hattori A, Hayashi A, Kozuma S, Hori T, Saito T (April 1999). „The human regulator of G-protein signaling protein 6 gene (RGS6) maps between markers WI-5202 and D14S277 on chromosome 14q24.3”. J Hum Genet 44 (2): 138–40. DOI:10.1007/s100380050129. PMID 10083744.
- ↑ 2,0 2,1 Liu Z, Fisher RA (March 2004). „RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity”. J Biol Chem 279 (14): 14120–8. DOI:10.1074/jbc.M309547200. PMID 14734556. Greška u referenci: Nevaljana oznaka
<ref>; naziv "pmid14734556" je zadan više puta s različitim sadržajem - ↑ 3,0 3,1 „Entrez Gene: RGS6 regulator of G-protein signalling 6”.
- ↑ Liu, Zhengyu; Chatterjee Tapan K; Fisher Rory A (October 2002). „RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6”. J. Biol. Chem. (United States) 277 (40): 37832–9. DOI:10.1074/jbc.M205908200. ISSN 0021-9258. PMID 12140291.
Literatura
- Sherrington R, Rogaev EI, Liang Y, et al. (1995). „Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease”. Nature 375 (6534): 754–60. DOI:10.1038/375754a0. PMID 7596406.
- Snow BE, Betts L, Mangion J, et al. (1999). „Fidelity of G protein β-subunit association by the G protein γ-subunit-like domains of RGS6, RGS7, and RGS11”. Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6489–94. DOI:10.1073/pnas.96.11.6489. PMC 26909. PMID 10339615.
- Posner BA, Gilman AG, Harris BA (1999). „Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways”. J. Biol. Chem. 274 (43): 31087–93. DOI:10.1074/jbc.274.43.31087. PMID 10521509.
- Liu Z, Chatterjee TK, Fisher RA (2002). „RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6”. J. Biol. Chem. 277 (40): 37832–9. DOI:10.1074/jbc.M205908200. PMID 12140291.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Chatterjee TK, Fisher RA (2003). „Mild heat and proteotoxic stress promote unique subcellular trafficking and nucleolar accumulation of RGS6 and other RGS proteins. Role of the RGS domain in stress-induced trafficking of RGS proteins”. J. Biol. Chem. 278 (32): 30272–82. DOI:10.1074/jbc.M212688200. PMID 12761220.
- Chatterjee TK, Liu Z, Fisher RA (2003). „Human RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants”. J. Biol. Chem. 278 (32): 30261–71. DOI:10.1074/jbc.M212687200. PMID 12761221.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
- p
- r
- u
PDB Galerija
|
