Izovaleril-KoA dehidrogenaza
| Izovaleril-KoA dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Tetramer izovaleril-KoA dehidrogenaze (čovjek) | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.3.8.4 | ||||||||
| CAS broj | 37274-61-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Izovaleril-KoA dehidrogenaza (EC 1.3.8.4, izovaleril-koenzim A dehidrogenaza, izovaleroil-koenzim A dehidrogenaza, 3-metilbutanoil-KoA:(akceptor) oksidoreduktaza) je enzim sa sistematskim imenom 3-metilbutanoil-KoA:elektron-transfer flavoprotein oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju:
- izovaleril-KoA + elektron-transfer flavoprotein 3-metilkrotonil-KoA + redukovani elektron-transfer flavoprotein
Ovaj enzim sadrži FAD kao prostetičku grupu. Pentanoat može da deluje kao donor.
Reference
- ↑ Bachhawat, B.K., Robinson, W.G. and Coon, M.J. (1956). „Enzymatic carboxylation of β-hydroxyisovaleryl coenzyme A”. J. Biol. Chem. 219: 539-550. PMID 13319276.
- ↑ Ikeda, Y. and Tanaka, K. (1983). „Purification and characterization of isovaleryl coenzyme A dehydrogenase from rat liver mitochondria”. J. Biol. Chem. 258: 1077-1085. PMID 6401713.
- ↑ Tanaka, K., Budd, M.A., Efron, M.L. and Isselbacher, K.J. (1966). „Isovaleric acidemia: a new genetic defect of leucine metabolism”. Proc. Natl. Acad. Sci. USA 56: 236-242. PMID 5229850.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Spoljašnje veze
- MeSH Isovaleryl-CoA+dehydrogenase
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
