HIF1A |
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PDBに登録されている構造 |
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PDB | オルソログ検索: RCSB PDBe PDBj |
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PDBのIDコード一覧 |
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1H2K, 1H2L, 1H2M, 1L3E, 1L8C, 1LM8, 1LQB, 2ILM, 3HQR, 3HQU, 4AJY, 4H6J |
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識別子 |
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記号 | HIF1A, HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78, hypoxia inducible factor 1 alpha subunit, hypoxia inducible factor 1 subunit alpha, HIF-1α |
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外部ID | OMIM: 603348 MGI: 106918 HomoloGene: 1171 GeneCards: HIF1A |
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遺伝子の位置 (ヒト) |
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| 染色体 | 14番染色体 (ヒト)[1] |
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| バンド | データ無し | 開始点 | 61,695,513 bp[1] |
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終点 | 61,748,259 bp[1] |
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遺伝子の位置 (マウス) |
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| 染色体 | 12番染色体 (マウス)[2] |
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| バンド | データ無し | 開始点 | 73,948,149 bp[2] |
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終点 | 73,994,304 bp[2] |
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遺伝子オントロジー |
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分子機能 | • protein dimerization activity • DNA-binding transcription factor activity • DNA-binding transcription activator activity, RNA polymerase II-specific • ヒストンデアセチラーゼ結合 • 転写因子結合 • 酵素結合 • 血漿タンパク結合 • histone acetyltransferase binding • プロテインキナーゼ結合 • Hsp90タンパク質結合 • sequence-specific DNA binding • DNA結合 • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • ubiquitin protein ligase binding • protein heterodimerization activity • E-box binding • p53結合 • protein domain specific binding • DNA-binding transcription factor activity, RNA polymerase II-specific • RNA polymerase II transcription regulatory region sequence-specific DNA binding
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細胞の構成要素 | • 細胞質 • 細胞質基質 • 細胞核 • nuclear speck • motile cilium • transcription regulator complex • RNA polymerase II transcription regulator complex • axon cytoplasm • 核質 • 核内構造体 • 高分子複合体
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生物学的プロセス | • negative regulation of neuron apoptotic process • B-1 B cell homeostasis • regulation of transforming growth factor beta2 production • muscle cell cellular homeostasis • outflow tract morphogenesis • negative regulation of ossification • heart looping • negative regulation of TOR signaling • 血管発生 • ヘモグロビン生合成プロセス • 血管新生 • positive regulation of chemokine-mediated signaling pathway • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of hormone biosynthetic process • negative regulation of mesenchymal cell apoptotic process • regulation of aerobic respiration • positive regulation of neuroblast proliferation • dopaminergic neuron differentiation • lactate metabolic process • regulation of transcription, DNA-templated • blood vessel morphogenesis • positive regulation of erythrocyte differentiation • glucose homeostasis • vascular endothelial growth factor production • regulation of thymocyte apoptotic process • positive regulation of epithelial cell migration • negative regulation of thymocyte apoptotic process • transcription, DNA-templated • positive regulation of transcription, DNA-templated • axonal transport of mitochondrion • positive regulation of macroautophagy • 軟骨形成 • positive regulation of nitric-oxide synthase activity • regulation of transcription from RNA polymerase II promoter in response to hypoxia • 授乳 • negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway • positive regulation of pri-miRNA transcription by RNA polymerase II • digestive tract morphogenesis • 細胞分化 • neural fold elevation formation • positive regulation of autophagy • retina vasculature development in camera-type eye • collagen metabolic process • embryonic placenta development • negative regulation of apoptotic process • positive regulation of angiogenesis • regulation of glycolytic process • 上皮間葉転換 • 大脳皮質発生 • 遺伝子発現調節 • positive regulation of chemokine production • intestinal epithelial cell maturation • regulation of catalytic activity • positive regulation of autophagy of mitochondrion • cardiac ventricle morphogenesis • response to muscle activity • epithelial cell differentiation involved in mammary gland alveolus development • visual learning • positive regulation of vascular endothelial growth factor receptor signaling pathway • negative regulation of bone mineralization • negative regulation of growth • 低酸素症への反応 • positive regulation of endothelial cell proliferation • regulation of transcription from RNA polymerase II promoter in response to oxidative stress • iris morphogenesis • mRNA transcription by RNA polymerase II • hypoxia-inducible factor-1alpha signaling pathway • 脈管構造発生 • regulation of cell population proliferation • neural crest cell migration • embryonic hemopoiesis • connective tissue replacement involved in inflammatory response wound healing • positive regulation of transcription from RNA polymerase II promoter in response to hypoxia • negative regulation of reactive oxygen species metabolic process • positive regulation of vascular endothelial growth factor production • elastin metabolic process • positive regulation of glycolytic process • oxygen homeostasis • シグナル伝達 • positive regulation of transcription by RNA polymerase II • cellular iron ion homeostasis • camera-type eye morphogenesis • cellular response to hypoxia • cellular response to interleukin-1 • transcription by RNA polymerase II • protein deubiquitination • 翻訳後修飾 • response to iron ion • 遺伝子発現の負の調節 • positive regulation of blood vessel endothelial cell migration • positive regulation of gene expression • サイトカイン媒介シグナル伝達経路 • regulation of transcription by RNA polymerase II • protein ubiquitination
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出典:Amigo / QuickGO |
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オルソログ |
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種 | ヒト | マウス |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_181054 NM_001243084 NM_001530 |
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NM_010431 NM_001313919 NM_001313920 |
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RefSeq (タンパク質) | |
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NP_001230013 NP_001521 NP_851397 NP_001521.1 |
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NP_001300848 NP_001300849 NP_034561 |
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場所 (UCSC) | Chr 14: 61.7 – 61.75 Mb | Chr 14: 73.95 – 73.99 Mb |
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PubMed検索 | [3] | [4] |
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ウィキデータ |
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