SDHB

Pengidentifikasi

Alias

SDHB, CWS2, IP, PGL4, SDH, SDH1, SDH2, SDHIP, succinate dehydrogenase complex iron sulfur subunit B, MC2DN4

ID eksternal

OMIM: 185470 MGI: 1914930 HomoloGene: 2255 GeneCards: SDHB

Ontologi gen
Fungsi molekuler	• ubiquinone binding • iron-sulfur cluster binding • metal ion binding • succinate dehydrogenase (ubiquinone) activity • GO:0001948, GO:0016582 Ikatan protein plasma • oxidoreductase activity • electron transfer activity • 2 iron, 2 sulfur cluster binding • 3 iron, 4 sulfur cluster binding • 4 iron, 4 sulfur cluster binding
Komponen seluler	• membran • Membran sel • nucleoplasm • mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) • mitochondrial inner membrane • mitokondria • mitochondrial membranes • respiratory chain complex II
Proses biologis	• succinate metabolic process • aerobic respiration • Siklus asam sitrat • respiratory electron transport chain • Rantai transpor elektron
Sumber:Amigo / QuickGO

Ortolog

Spesies

Manusia

Tikus

Entrez


6390


67680

Ensembl


ENSG00000117118


ENSMUSG00000009863

UniProt


P21912


Q9CQA3

RefSeq (mRNA)


NM_003000


NM_023374 NM_001355515

RefSeq (protein)


NP_002991


NP_075863 NP_001342444

Lokasi (UCSC)

n/a

Pencarian PubMed

^[1]

^[2]

Wikidata

Lihat/Sunting Manusia

Lihat/Sunting Tikus

SDHB adalah berkas genetik pada kromosom 1 lokasi 1p36.1-p35 dengan ekspresi genetik berupa protein sub-unit B dari suksinat dehidrogenase. Sub-unit B terdiri dari 3 kluster yang kaya akan sisteina. Mutasi pada gen akan menyebabkan paraganglioma dan feokromositoma, disfungsi mitokondria dan tumorigenesis.^[3]

Referensi

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ (Inggris) "SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) [ Homo sapiens ]". Entrez Gene. Diakses tanggal 2010-11-05.