TLR3 |
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Structures disponibles |
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PDB | Recherche d'orthologue: PDBe RCSB |
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Identifiants PDB |
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1ZIW, 2A0Z, 3ULU, 3ULV, 2MK9, 2MKA |
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Identifiants |
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Aliases | TLR3, CD283 |
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IDs externes | OMIM: 603029 MGI: 2156367 HomoloGene: 20696 GeneCards: TLR3 |
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Position du gène (Homme) |
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| Chr. | Chromosome 4 humain[1] |
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| Locus | 4q35.1 | Début | 186,069,155 bp[1] |
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Fin | 186,088,073 bp[1] |
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Position du gène (Souris) |
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| Chr. | Chromosome 8 (souris)[2] |
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| Locus | 8|8 B1.1 | Début | 45,848,702 bp[2] |
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Fin | 45,864,117 bp[2] |
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Expression génétique |
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Bgee | Humain | Souris (orthologue) |
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Fortement exprimé dans | - muqueuse jéjunale
- palpebral conjunctiva
- placenta
- rectum
- sperme
- duodénum
- vésicule biliaire
- tendon calcanéen
- epithelium of colon
- pancreatic epithelial cell
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| Fortement exprimé dans | - conjunctival fornix
- gastrula
- strie vasculaire
- transitional epithelium of urinary bladder
- vestibular membrane of cochlear duct
- vestibular sensory epithelium
- secondary oocyte
- lumbar subsegment of spinal cord
- Epithelium of choroid plexus
- Jéjunum
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| Plus de données d'expression de référence |
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BioGPS | | Plus de données d'expression de référence |
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Gene Ontology |
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Fonction moléculaire | - liaison protéique
- identical protein binding
- liaison ARN
- liaison ARN double brin
- transmembrane signaling receptor activity
- signaling receptor activity
| Composant cellulaire | - cytoplasme
- integral component of membrane
- endosome
- membrane du réticulum endoplasmique
- membrane
- Golgi membrane
- integral component of plasma membrane
- intracellulaire
- surface cellulaire
- lysosomal membrane
- early endosome
- réticulum endoplasmique
- endolysosome membrane
- endosome membrane
- milieu extracellulaire
- matrice extracellulaire
| Processus biologique | - positive regulation of interferon-beta production
- response to dsRNA
- réponse de défense
- positive regulation of toll-like receptor signaling pathway
- positive regulation of protein phosphorylation
- male gonad development
- positive regulation of inflammatory response
- positive regulation of interleukin-12 production
- positive regulation of type III interferon production
- cellular response to interferon-beta
- response to exogenous dsRNA
- negative regulation of osteoclast differentiation
- positive regulation of cytokine production
- processus du système immunitaire
- response to virus
- activation of NF-kappaB-inducing kinase activity
- I-kappaB phosphorylation
- positive regulation of JNK cascade
- hyperosmotic response
- cellular response to dsRNA
- regulation of dendritic cell cytokine production
- microglial cell activation
- toll-like receptor signaling pathway
- TRIF-dependent toll-like receptor signaling pathway
- cellular response to mechanical stimulus
- microglial cell activation involved in immune response
- positive regulation of gene expression
- defense response to bacterium
- positive regulation of NF-kappaB transcription factor activity
- defense response to virus
- necroptotic signaling pathway
- positive regulation of interleukin-8 production
- cellular response to exogenous dsRNA
- positive regulation of interleukin-6 production
- positive regulation of tumor necrosis factor production
- cellular response to interferon-gamma
- positive regulation of chemokine production
- positive regulation of apoptotic process
- positive regulation of I-kappaB kinase/NF-kappaB signaling
- detection of virus
- réponse inflammatoire
- système immunitaire inné
- I-kappaB kinase/NF-kappaB signaling
- toll-like receptor 3 signaling pathway
- positive regulation of type I interferon production
- MyD88-independent toll-like receptor signaling pathway
- transduction de signal
- positive regulation of transcription by RNA polymerase II
- Nécrose programmée
- apoptotic signaling pathway
- negative regulation of MyD88-independent toll-like receptor signaling pathway
- extrinsic apoptotic signaling pathway
- positive regulation of angiogenesis
- positive regulation of NIK/NF-kappaB signaling
| Sources:Amigo / QuickGO |
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Orthologues |
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Espèces | Homme | Souris |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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NM_126166 NM_001357316 NM_001357317 |
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RefSeq (protéine) | | |
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NP_569054 NP_001344245 NP_001344246 |
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Localisation (UCSC) | Chr 4: 186.07 – 186.09 Mb | Chr 8: 45.85 – 45.86 Mb |
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Publication PubMed | [3] | [4] |
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Wikidata |
Voir/Editer Humain | Voir/Editer Souris |
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