YBX2

Protein-coding gene in the species Homo sapiens
YBX2
Identifiers
AliasesYBX2, CONTRIN, CSDA3, DBPC, MSY2, Y-box binding protein 2
External IDsOMIM: 611447; MGI: 1096372; HomoloGene: 22942; GeneCards: YBX2; OMA:YBX2 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for YBX2
Genomic location for YBX2
Band17p13.1Start7,288,263 bp[1]
End7,294,639 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for YBX2
Genomic location for YBX2
Band11|11 B3Start69,935,796 bp[2]
End69,941,605 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right testis

  • left testis

  • mucosa of transverse colon

  • duodenum

  • gonad

  • medulla oblongata

  • testicle

  • rectum

  • skeletal muscle tissue

  • muscle of thigh
Top expressed in
  • seminiferous tubule

  • spermatid

  • spermatocyte

  • zygote

  • primary oocyte

  • secondary oocyte

  • muscle of thigh

  • neural layer of retina

  • interventricular septum

  • genital tubercle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • RNA binding
  • nucleic acid binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • cytoplasm
  • nucleus
  • fibrillar center
Biological process
  • regulation of transcription, DNA-templated
  • translational attenuation
  • transcription by RNA polymerase II
  • spermatogenesis
  • oocyte development
  • regulation of transcription by RNA polymerase II
  • positive regulation of cold-induced thermogenesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51087

53422

Ensembl

ENSG00000006047
ENSG00000288504

ENSMUSG00000018554

UniProt

Q9Y2T7

Q9Z2C8

RefSeq (mRNA)

NM_015982

NM_016875
NM_001347634

RefSeq (protein)

NP_057066

n/a

Location (UCSC)Chr 17: 7.29 – 7.29 MbChr 11: 69.94 – 69.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Y-box-binding protein 2 is a protein that in humans is encoded by the YBX2 gene.[5][6][7]

See also


References

  1. ^ a b c ENSG00000288504 GRCh38: Ensembl release 89: ENSG00000006047, ENSG00000288504 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018554 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tekur S, Pawlak A, Guellaen G, Hecht NB (Jul 1999). "Contrin, the human homologue of a germ-cell Y-box-binding protein: cloning, expression, and chromosomal localization". J Androl. 20 (1): 135–44. doi:10.1002/j.1939-4640.1999.tb02506.x. PMID 10100484.
  6. ^ Gu W, Tekur S, Reinbold R, Eppig JJ, Choi YC, Zheng JZ, Murray MT, Hecht NB (Dec 1998). "Mammalian male and female germ cells express a germ cell-specific Y-Box protein, MSY2". Biol Reprod. 59 (5): 1266–74. doi:10.1095/biolreprod59.5.1266. PMID 9780336.
  7. ^ "Entrez Gene: YBX2 Y box binding protein 2".

Further reading

  • Hammoud S, Emery BR, Dunn D, et al. (2009). "Sequence alterations in the YBX2 gene are associated with male factor infertility". Fertil. Steril. 91 (4): 1090–5. doi:10.1016/j.fertnstert.2008.01.009. PMID 18339382.
  • Yoshida T, Izumi H, Uchiumi T, et al. (2006). "Expression and cellular localization of dbpC/Contrin in germ cell tumor cell lines". Biochim. Biophys. Acta. 1759 (1–2): 80–8. doi:10.1016/j.bbaexp.2006.02.005. PMID 16624424.
  • Kohno Y, Matsuki Y, Tanimoto A, et al. (2006). "Expression of Y-box-binding protein dbpC/contrin, a potentially new cancer/testis antigen". Br. J. Cancer. 94 (5): 710–6. doi:10.1038/sj.bjc.6602987. PMC 2361212. PMID 16479255.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • v
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  • 1h95: SOLUTION STRUCTURE OF THE SINGLE-STRANDED DNA-BINDING COLD SHOCK DOMAIN (CSD) OF HUMAN Y-BOX PROTEIN 1 (YB1) DETERMINED BY NMR (10 LOWEST ENERGY STRUCTURES)
    1h95: SOLUTION STRUCTURE OF THE SINGLE-STRANDED DNA-BINDING COLD SHOCK DOMAIN (CSD) OF HUMAN Y-BOX PROTEIN 1 (YB1) DETERMINED BY NMR (10 LOWEST ENERGY STRUCTURES)


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