VTCN1

Protein-coding gene in the species Homo sapiens

VTCN1

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
4GOS

Identifiers

Aliases

VTCN1, B7-H4, B7H4, B7S1, B7X, B7h.5, PRO1291, VCTN1, V-set domain containing T cell activation inhibitor 1, V-set domain containing T-cell activation inhibitor 1

External IDs

OMIM: 608162; MGI: 3039619; HomoloGene: 11627; GeneCards: VTCN1; OMA:VTCN1 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p13.1-p12	Start	117,143,587 bp^[1]
Band	1p13.1-p12	End	117,210,960 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3\|3 F2.2	Start	100,732,775 bp^[2]
Band	3\|3 F2.2	End	100,804,238 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

palpebral conjunctiva

epithelium of lactiferous gland

lactiferous duct

hair follicle

right uterine tube

islet of Langerhans

nasal epithelium

body of pancreas

olfactory zone of nasal mucosa

secondary oocyte

Top expressed in

blastocyst

morula

spermatid

uterus

ascending aorta

aortic valve

cervix

esophagus

proximal tubule

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	signaling receptor binding molecular function
Cellular component	integral component of membrane plasma membrane membrane external side of plasma membrane
Biological process	adaptive immune response positive regulation of T cell proliferation response to protozoan immune system process negative regulation of T cell proliferation negative regulation of apoptotic process negative regulation of T cell activation regulation of immune response T cell receptor signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


79679


242122

Ensembl


ENSG00000134258


ENSMUSG00000051076

UniProt


Q7Z7D3


Q7TSP5

RefSeq (mRNA)


NM_001253849 NM_001253850 NM_024626


NM_178594

RefSeq (protein)


NP_001240778 NP_001240779 NP_078902


NP_848709

Location (UCSC)

Chr 1: 117.14 – 117.21 Mb

Chr 3: 100.73 – 100.8 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

V-set domain-containing T-cell activation inhibitor 1 is a protein that in humans is encoded by the VTCN1 gene.^[5]^[6]^[7]

Function

B7H4 belongs to the B7 family (see CD80; MIM 112203) of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands (e.g., CD28; MIM 186760) on T lymphocytes.[supplied by OMIM]^[7]

B7-H4 is an immune checkpoint molecule.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134258 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000051076 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sica GL, Choi IH, Zhu G, Tamada K, Wang SD, Tamura H, Chapoval AI, Flies DB, Bajorath J, Chen L (June 2003). "B7-H4, a molecule of the B7 family, negatively regulates T cell immunity". Immunity. 18 (6): 849–61. doi:10.1016/S1074-7613(03)00152-3. PMID 12818165.
^ Prasad DV, Richards S, Mai XM, Dong C (June 2003). "B7S1, a novel B7 family member that negatively regulates T cell activation". Immunity. 18 (6): 863–73. doi:10.1016/S1074-7613(03)00147-X. PMID 12818166.
^ ^a ^b "Entrez Gene: VTCN1 V-set domain containing T cell activation inhibitor 1".

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