TIMM23

Protein-coding gene in the species Homo sapiens
TIMM23B
Identifiers
AliasesTIMM23B, TIMM23, bA592B15.7, translocase of inner mitochondrial membrane 23 homolog B
External IDsHomoloGene: 140621; GeneCards: TIMM23B; OMA:TIMM23B - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for TIMM23B
Genomic location for TIMM23B
Band10q11.23Start49,942,049 bp[1]
End49,974,850 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tibialis anterior muscle

  • deltoid muscle

  • mucosa of ileum

  • myocardium of left ventricle

  • quadriceps femoris muscle

  • vastus lateralis muscle

  • biceps brachii

  • pancreatic ductal cell

  • Skeletal muscle tissue of biceps brachii

  • nipple
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein-transporting ATPase activity
  • molecular function
  • protein transmembrane transporter activity
Cellular component
  • membrane
  • integral component of mitochondrial inner membrane
  • TIM23 mitochondrial import inner membrane translocase complex
  • integral component of membrane
  • mitochondrion
  • mitochondrial inner membrane
  • cellular component
Biological process
  • protein import into mitochondrial matrix
  • intracellular protein transport
  • protein transport
  • biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

100652748

n/a

Ensembl

ENSG00000204152

n/a

UniProt

Q5SRD1

n/a

RefSeq (mRNA)

NM_001290117
NM_001290118
NM_001365871

n/a

RefSeq (protein)

NP_001277046
NP_001277047
NP_001352800

n/a

Location (UCSC)Chr 10: 49.94 – 49.97 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Mitochondrial import inner membrane translocase subunit Tim23 is an enzyme that in humans is encoded by the TIMM23 gene.[3][4]


See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000204152 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Bauer MF, Gempel K, Reichert AS, Rappold GA, Lichtner P, Gerbitz KD, Neupert W, Brunner M, Hofmann S (Jul 1999). "Genetic and structural characterization of the human mitochondrial inner membrane translocase". J Mol Biol. 289 (1): 69–82. doi:10.1006/jmbi.1999.2751. PMID 10339406.
  4. ^ "Entrez Gene: TIMM23 translocase of inner mitochondrial membrane 23 homolog (yeast)".

Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Guo Y, Cheong N, Zhang Z, et al. (2004). "Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death". J. Biol. Chem. 279 (23): 24813–25. doi:10.1074/jbc.M402049200. PMID 15044455.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Yamamoto H, Esaki M, Kanamori T, et al. (2002). "Tim50 is a subunit of the TIM23 complex that links protein translocation across the outer and inner mitochondrial membranes". Cell. 111 (4): 519–28. doi:10.1016/S0092-8674(02)01053-X. PMID 12437925. S2CID 18869447.
  • Moro F, Sirrenberg C, Schneider HC, et al. (1999). "The TIM17.23 preprotein translocase of mitochondria: composition and function in protein transport into the matrix". EMBO J. 18 (13): 3667–75. doi:10.1093/emboj/18.13.3667. PMC 1171444. PMID 10393182.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.


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