TIMM13

Protein-coding gene in the species Homo sapiens
TIMM13
Identifiers
AliasesTIMM13, TIM13, TIM13B, TIMM13A, TIMM13B, ppv1, translocase of inner mitochondrial membrane 13
External IDsOMIM: 607383; MGI: 1353432; HomoloGene: 40846; GeneCards: TIMM13; OMA:TIMM13 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for TIMM13
Genomic location for TIMM13
Band19p13.3Start2,425,625 bp[1]
End2,427,586 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for TIMM13
Genomic location for TIMM13
Band10 C1|10 39.72 cMStart80,735,284 bp[2]
End80,736,803 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of transverse colon

  • apex of heart

  • right adrenal gland

  • right adrenal cortex

  • left adrenal gland

  • left adrenal cortex

  • right lobe of liver

  • prefrontal cortex

  • muscle of thigh

  • body of pancreas
Top expressed in
  • yolk sac

  • proximal tubule

  • right kidney

  • neural tube

  • white adipose tissue

  • quadriceps femoris muscle

  • adrenal gland

  • blastocyst

  • pancreas

  • mesencephalon
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • zinc ion binding
  • metal ion binding
Cellular component
  • mitochondrial intermembrane space protein transporter complex
  • membrane
  • mitochondrion
  • fibrillar center
  • mitochondrial inner membrane
  • mitochondrial intermembrane space
Biological process
  • protein transport
  • protein targeting to mitochondrion
  • hearing
  • protein insertion into mitochondrial inner membrane
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26517

30055

Ensembl

ENSG00000099800

ENSMUSG00000020219

UniProt

Q9Y5L4

P62075

RefSeq (mRNA)

NM_012458

NM_013895

RefSeq (protein)

NP_036590

NP_038923

Location (UCSC)Chr 19: 2.43 – 2.43 MbChr 10: 80.74 – 80.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mitochondrial import inner membrane translocase subunit Tim13 is an enzyme that in humans is encoded by the TIMM13 gene.[5][6][7]

Function

This gene encodes a translocase with similarity to yeast mitochondrial proteins that are involved in the import of metabolite transporters from the cytoplasm and into the mitochondrial inner membrane. The encoded protein and the TIMM8a protein form a 70 kDa complex in the intermembrane space. This gene is in a head-to-tail orientation with the gene for lamin B2.[7]

Interactions

TIMM13 has been shown to interact with TIMM8A.[8][9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000099800 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020219 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jin H, Kendall E, Freeman TC, Roberts RG, Vetrie DL (Nov 1999). "The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins". Genomics. 61 (3): 259–67. doi:10.1006/geno.1999.5966. PMID 10552927.
  6. ^ Gentle IE, Perry AJ, Alcock FH, Likić VA, Dolezal P, Ng ET, Purcell AW, McConnville M, Naderer T, Chanez AL, Charrière F, Aschinger C, Schneider A, Tokatlidis K, Lithgow T (May 2007). "Conserved motifs reveal details of ancestry and structure in the small TIM chaperones of the mitochondrial intermembrane space". Molecular Biology and Evolution. 24 (5): 1149–60. doi:10.1093/molbev/msm031. PMID 17329230.
  7. ^ a b "Entrez Gene: TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)".
  8. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  9. ^ Roesch K, Curran SP, Tranebjaerg L, Koehler CM (Mar 2002). "Human deafness dystonia syndrome is caused by a defect in assembly of the DDP1/TIMM8a-TIMM13 complex". Human Molecular Genetics. 11 (5): 477–86. doi:10.1093/hmg/11.5.477. PMID 11875042.

Further reading

  • Rehling P, Wiedemann N, Pfanner N, Truscott KN (2001). "The mitochondrial import machinery for preproteins". Critical Reviews in Biochemistry and Molecular Biology. 36 (3): 291–336. doi:10.1080/20014091074200. PMID 11450972. S2CID 8758017.
  • Paschen SA, Neupert W (2002). "Protein import into mitochondria". IUBMB Life. 52 (3–5): 101–12. doi:10.1080/15216540152845894. PMID 11798021. S2CID 31047665.
  • Neupert W, Brunner M (Aug 2002). "The protein import motor of mitochondria". Nature Reviews. Molecular Cell Biology. 3 (8): 555–65. doi:10.1038/nrm878. PMID 12154367. S2CID 5706589.
  • Jensen RE, Dunn CD (Sep 2002). "Protein import into and across the mitochondrial inner membrane: role of the TIM23 and TIM22 translocons". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1592 (1): 25–34. doi:10.1016/S0167-4889(02)00261-6. PMID 12191765.
  • Bauer MF, Rothbauer U, Mühlenbein N, Smith RJ, Gerbitz K, Neupert W, Brunner M, Hofmann S (Dec 1999). "The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom". FEBS Letters. 464 (1–2): 41–7. doi:10.1016/S0014-5793(99)01665-8. PMID 10611480. S2CID 27484018.
  • Paschen SA, Rothbauer U, Káldi K, Bauer MF, Neupert W, Brunner M (Dec 2000). "The role of the TIM8-13 complex in the import of Tim23 into mitochondria". The EMBO Journal. 19 (23): 6392–400. doi:10.1093/emboj/19.23.6392. PMC 305865. PMID 11101512.
  • Rothbauer U, Hofmann S, Mühlenbein N, Paschen SA, Gerbitz KD, Neupert W, Brunner M, Bauer MF (Oct 2001). "Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria". The Journal of Biological Chemistry. 276 (40): 37327–34. doi:10.1074/jbc.M105313200. PMID 11489896.
  • Roesch K, Curran SP, Tranebjaerg L, Koehler CM (Mar 2002). "Human deafness dystonia syndrome is caused by a defect in assembly of the DDP1/TIMM8a-TIMM13 complex". Human Molecular Genetics. 11 (5): 477–86. doi:10.1093/hmg/11.5.477. PMID 11875042.
  • Chacinska A, Pfanner N, Meisinger C (Jul 2002). "How mitochondria import hydrophilic and hydrophobic proteins". Trends in Cell Biology. 12 (7): 299–303. doi:10.1016/S0962-8924(02)02310-3. PMID 12185844.
  • Curran SP, Leuenberger D, Schmidt E, Koehler CM (Sep 2002). "The role of the Tim8p-Tim13p complex in a conserved import pathway for mitochondrial polytopic inner membrane proteins". The Journal of Cell Biology. 158 (6): 1017–27. doi:10.1083/jcb.200205124. PMC 2173223. PMID 12221072.
  • Roesch K, Hynds PJ, Varga R, Tranebjaerg L, Koehler CM (Sep 2004). "The calcium-binding aspartate/glutamate carriers, citrin and aralar1, are new substrates for the DDP1/TIMM8a-TIMM13 complex". Human Molecular Genetics. 13 (18): 2101–11. doi:10.1093/hmg/ddh217. PMID 15254020.
  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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