STK25

Protein-coding gene in the species Homo sapiens
STK25
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2XIK, 3W8H, 4NZW

Identifiers
AliasesSTK25, SOK1, YSK1, serine/threonine kinase 25
External IDsOMIM: 602255; MGI: 1891699; HomoloGene: 48428; GeneCards: STK25; OMA:STK25 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for STK25
Genomic location for STK25
Band2q37.3Start241,492,670 bp[1]
End241,509,730 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for STK25
Genomic location for STK25
Band1 D|1 47.25 cMStart93,547,473 bp[2]
End93,586,381 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • muscle of thigh

  • right lobe of thyroid gland

  • right hemisphere of cerebellum

  • gastrocnemius muscle

  • left lobe of thyroid gland

  • right frontal lobe

  • apex of heart

  • ventricular zone

  • anterior pituitary

  • ganglionic eminence
Top expressed in
  • spermatocyte

  • dentate gyrus of hippocampal formation granule cell

  • neural layer of retina

  • spermatid

  • superior frontal gyrus

  • ventricular zone

  • genital tubercle

  • muscle of thigh

  • right ventricle

  • tail of embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • protein kinase activity
  • nucleotide binding
  • protein homodimerization activity
  • metal ion binding
  • kinase activity
  • protein binding
  • ATP binding
  • protein serine/threonine kinase activity
  • MAP kinase kinase kinase kinase activity
Cellular component
  • cytoplasm
  • Golgi apparatus
  • Golgi membrane
  • extracellular exosome
Biological process
  • intrinsic apoptotic signaling pathway in response to hydrogen peroxide
  • phosphorylation
  • response to oxidative stress
  • positive regulation of axonogenesis
  • establishment of Golgi localization
  • Golgi reassembly
  • establishment or maintenance of cell polarity
  • protein phosphorylation
  • Golgi localization
  • protein autophosphorylation
  • response to hydrogen peroxide
  • signal transduction
  • positive regulation of stress-activated MAPK cascade
  • MAPK cascade
  • regulation of mitotic cell cycle
  • regulation of apoptotic process
  • neuron projection morphogenesis
  • stress-activated protein kinase signaling cascade
  • activation of protein kinase activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10494

59041

Ensembl

ENSG00000115694

ENSMUSG00000026277

UniProt

O00506

Q9Z2W1

RefSeq (mRNA)
NM_001271977
NM_001271978
NM_001271979
NM_001271980
NM_001282305

NM_001282306
NM_001282307
NM_001282308
NM_006374

NM_021537

RefSeq (protein)
NP_001258906
NP_001258907
NP_001258908
NP_001258909
NP_001269234

NP_001269235
NP_001269236
NP_001269237
NP_006365

NP_067512

Location (UCSC)Chr 2: 241.49 – 241.51 MbChr 1: 93.55 – 93.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase 25 is an enzyme that in humans is encoded by the STK25 gene.[5][6][7][8]

Interactions

STK25 has been shown to interact with STRN,[9] PDCD10[10] and MOBKL3.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115694 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026277 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Pombo CM, Bonventre JV, Molnar A, Kyriakis J, Force T (Jan 1997). "Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway". EMBO J. 15 (17): 4537–46. doi:10.1002/j.1460-2075.1996.tb00831.x. PMC 452183. PMID 8887545.
  6. ^ Osada S, Izawa M, Saito R, Mizuno K, Suzuki A, Hirai S, Ohno S (Jun 1997). "YSK1, a novel mammalian protein kinase structurally related to Ste20 and SPS1, but is not involved in the known MAPK pathways". Oncogene. 14 (17): 2047–57. doi:10.1038/sj.onc.1201043. PMID 9160885. S2CID 27210425.
  7. ^ Preisinger C, Short B, De Corte V, Bruyneel E, Haas A, Kopajtich R, Gettemans J, Barr FA (Mar 2004). "YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta". J Cell Biol. 164 (7): 1009–20. doi:10.1083/jcb.200310061. PMC 2172068. PMID 15037601.
  8. ^ "Entrez Gene: STK25 serine/threonine kinase 25 (STE20 homolog, yeast)".
  9. ^ a b Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (January 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell. Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.
  10. ^ Rual JF, Venkatesan K, Hao T, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Findlay GM, Yan L, Procter J, et al. (2007). "A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling". Biochem. J. 403 (1): 13–20. doi:10.1042/BJ20061881. PMC 1828895. PMID 17253963.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Matsuki T, Matthews RT, Cooper JA, van der Brug MP, Cookson MR, Hardy JA, Olson EC, Howell BW (November 2010). "Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deployment". Cell. 143 (5): 826–36. doi:10.1016/j.cell.2010.10.029. PMC 3033572. PMID 21111240.


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