SEZ6

Protein-coding gene in the species Homo sapiens
SEZ6
Identifiers
AliasesSEZ6, BSRPC, seizure related 6 homolog
External IDsOMIM: 616666; MGI: 104745; HomoloGene: 10948; GeneCards: SEZ6; OMA:SEZ6 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for SEZ6
Genomic location for SEZ6
Band17q11.2Start28,954,901 bp[1]
End29,006,440 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for SEZ6
Genomic location for SEZ6
Band11 B5|11 46.74 cMStart77,821,626 bp[2]
End77,869,874 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • right hemisphere of cerebellum

  • nucleus accumbens

  • caudate nucleus

  • putamen

  • prefrontal cortex

  • right frontal lobe

  • cingulate gyrus

  • anterior cingulate cortex

  • amygdala
Top expressed in
  • olfactory tubercle

  • superior frontal gyrus

  • nucleus accumbens

  • subiculum

  • CA3 field

  • perirhinal cortex

  • primary visual cortex

  • entorhinal cortex

  • dentate gyrus of hippocampal formation granule cell

  • anterior amygdaloid area
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

124925

20370

Ensembl

ENSG00000063015

ENSMUSG00000000632

UniProt

Q53EL9

Q7TSK2

RefSeq (mRNA)

NM_001098635
NM_001290202
NM_178860

NM_001291225
NM_021286

RefSeq (protein)

NP_001092105
NP_001277131
NP_849191

NP_001278154
NP_067261

Location (UCSC)Chr 17: 28.95 – 29.01 MbChr 11: 77.82 – 77.87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Seizure protein 6 homolog is a protein that in humans is encoded by the SEZ6 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000063015 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000632 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yu ZL, Jiang JM, Wu DH, Xie HJ, Jiang JJ, Zhou L, Peng L, Bao GS (January 2007). "Febrile seizures are associated with mutation of seizure-related (SEZ) 6, a brain-specific gene". Journal of Neuroscience Research. 85 (1): 166–72. doi:10.1002/jnr.21103. PMID 17086543. S2CID 24331881.
  6. ^ "Entrez Gene: SEZ6 seizure related 6 homolog (mouse)".

Further reading

  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Kim MH, Gunnersen JM, Tan SS (October 2002). "Localized expression of the seizure-related gene SEZ-6 in developing and adult forebrains". Mechanisms of Development. 118 (1–2): 171–4. doi:10.1016/S0925-4773(02)00238-1. PMID 12351182. S2CID 16791550.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Shimizu-Nishikawa K, Kajiwara K, Sugaya E (November 1995). "Cloning and characterization of seizure-related gene, SEZ-6". Biochemical and Biophysical Research Communications. 216 (1): 382–9. doi:10.1006/bbrc.1995.2635. PMID 7488116.
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