RALY

Protein-coding gene in the species Homo sapiens
RALY
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1WF1

Identifiers
AliasesRALY, HNRPCL2, P542, RALY heterogeneous nuclear ribonucleoprotein
External IDsOMIM: 614663; MGI: 97850; HomoloGene: 7216; GeneCards: RALY; OMA:RALY - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for RALY
Genomic location for RALY
Band20q11.22Start33,993,646 bp[1]
End34,108,308 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for RALY
Genomic location for RALY
Band2 H1|2 76.83 cMStart154,633,016 bp[2]
End154,709,181 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • granulocyte

  • ventricular zone

  • right lobe of thyroid gland

  • mucosa of transverse colon

  • left lobe of thyroid gland

  • left testis

  • right testis

  • ascending aorta

  • popliteal artery
Top expressed in
  • neural layer of retina

  • ventricular zone

  • yolk sac

  • granulocyte

  • lip

  • embryo

  • epiblast

  • tail of embryo

  • embryo

  • thymus
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • nucleic acid binding
  • transcription coregulator activity
  • RNA binding
Cellular component
  • catalytic step 2 spliceosome
  • spliceosomal complex
  • nucleus
Biological process
  • mRNA splicing, via spliceosome
  • mRNA processing
  • RNA splicing
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • regulation of nucleic acid-templated transcription
  • cholesterol homeostasis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

22913

19383

Ensembl

ENSG00000125970

ENSMUSG00000027593

UniProt

Q9UKM9

Q64012

RefSeq (mRNA)

NM_007367
NM_016732

NM_001139511
NM_001139512
NM_001139513
NM_023130

RefSeq (protein)

NP_031393
NP_057951

NP_001132983
NP_001132984
NP_001132985
NP_075619

Location (UCSC)Chr 20: 33.99 – 34.11 MbChr 2: 154.63 – 154.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RNA-binding protein Raly is a protein that in humans is encoded by the RALY gene.[5][6]

In infectious mononucleosis, anti-EBNA-1 antibodies are produced which cross-react with multiple normal human proteins. The cross-reactivity is due to anti-gly/ala antibodies that cross-react with host proteins containing configurations like those in the EBNA-1 repeat. One such antigen is RALY which is a member of the heterogeneous nuclear ribonucleoprotein gene family.[6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125970 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027593 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Khrebtukova I, Kuklin A, Woychik RP, Michaud EJ (Nov 1999). "Alternative processing of the human and mouse raly genes(1)". Biochim Biophys Acta. 1447 (1): 107–12. doi:10.1016/s0167-4781(99)00126-8. PMID 10500250.
  6. ^ a b "Entrez Gene: RALY RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))".

Further reading

  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Beranova-Giorgianni S, Zhao Y, Desiderio DM, Giorgianni F (2006). "Phosphoproteomic analysis of the human pituitary". Pituitary. 9 (2): 109–20. doi:10.1007/s11102-006-8916-x. PMID 16807684. S2CID 10789246.
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
  • Rhodes GH, Valbracht JR, Nguyen MD, Vaughan JH (1997). "The p542 gene encodes an autoantigen that cross-reacts with EBNA-1 of the Epstein Barr virus and which may be a heterogeneous nuclear ribonucleoprotein". J. Autoimmun. 10 (5): 447–54. doi:10.1006/jaut.1997.9996. PMID 9376072.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Vaughan JH, Valbracht JR, Nguyen MD, et al. (1995). "Epstein-Barr virus-induced autoimmune responses. I. Immunoglobulin M autoantibodies to proteins mimicking and not mimicking Epstein-Barr virus nuclear antigen-1". J. Clin. Invest. 95 (3): 1306–15. doi:10.1172/JCI117781. PMC 441470. PMID 7533788.
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  • 1wf1: Solution structure of RRM domain in RNA-binding protein NP_057951
    1wf1: Solution structure of RRM domain in RNA-binding protein NP_057951


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