Quinaprilat
Chemical compound
- None
- (3S)-2-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
- 82768-85-2
- 6352
- 97106
- 34SSX5LDE5
- ChEMBL1733
- DTXSID40868904
- Interactive image
- C[C@@H](C(=O)N1CC2=CC=CC=C2C[C@H]1C(=O)O)N[C@@H](CCC3=CC=CC=C3)C(=O)O
InChI
- InChI=1S/C23H26N2O5/c1-15(24-19(22(27)28)12-11-16-7-3-2-4-8-16)21(26)25-14-18-10-6-5-9-17(18)13-20(25)23(29)30/h2-10,15,19-20,24H,11-14H2,1H3,(H,27,28)(H,29,30)/t15-,19-,20-/m0/s1
- Key:FLSLEGPOVLMJMN-YSSFQJQWSA-N
Quinaprilat is the active metabolite of quinapril.[1]
References
- ^ Ferry JJ, Horvath AM, Sedman AJ, Latts JR, Colburn WA (1987). "Influence of food on the pharmacokinetics of quinapril and its active diacid metabolite, CI-928". Journal of Clinical Pharmacology. 27 (5): 397–9. doi:10.1002/j.1552-4604.1987.tb03037.x. PMID 3693584. S2CID 36546103.
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Antihypertensive drugs acting on the renin–angiotensin system (C09)
("-pril")
- Sulfhydryl-containing: Captopril
- Rentiapril
- Zofenopril (+nebivolol)
- Dicarboxylate-containing: Enalapril# (+lercanidipine, +nitrendipine)
- Benazepril (+amlodipine, +pimobendan)
- Cilazapril
- Delapril (+manidipine)
- Imidapril
- Lisinopril (+amlodipine, +HCT)
- Moexipril
- Perindopril (+amlodipine, +bisoprolol, +indapamide, +amlodipine and indapamide, +bisoprolol and amlodipine, +bisoprolol, amlodipine, and indapamide)
- Quinapril (+HCT)
- Ramipril (+amlodipine, +amlodipine and HCT, +bisoprolol, +felodipine)
- Spirapril
- Temocapril
- Trandolapril (+verapamil)
- Phosphonate-containing: Ceronapril
- Fosinopril (+HCT)
- Other/ungrouped: Alacepril
("-sartan")
- Azilsartan
- Candesartan (+amlodipine, +amlodipine and HCT)
- Eprosartan
- Fimasartan
- Irbesartan (+amlodipine, +amlodipine and HCT, +HCT)
- Losartan (+amlodipine, +HCT)
- Olmesartan (+amlodipine, +amlodipine and HCT, +HCT)
- Tasosartan§
- Telmisartan (+amlodipine, +amlodipine and HCT, +HCT)
- Valsartan (+aliskiren, +amlodipine, +amlodipine and HCT, +HCT, +lercanidipine, +nebivolol, +sacubitril)
("-kiren")
- Gemopatrilat
- Ilepatril
- Omapatrilat
- Sampatrilat
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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