OTUB2

Protein-coding gene in the species Homo sapiens
OTUB2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1TFF, 4FJV

Identifiers
AliasesOTUB2, C14orf137, OTB2, OTU2, OTU deubiquitinase, ubiquitin aldehyde binding 2
External IDsOMIM: 608338; MGI: 1915399; HomoloGene: 57056; GeneCards: OTUB2; OMA:OTUB2 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for OTUB2
Genomic location for OTUB2
Band14q32.12Start94,026,340 bp[1]
End94,048,930 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for OTUB2
Genomic location for OTUB2
Band12|12 EStart103,354,941 bp[2]
End103,372,609 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • left testis

  • right testis

  • skin of leg

  • ventricular zone

  • gonad

  • skin of abdomen

  • ganglionic eminence

  • placenta

  • islet of Langerhans
Top expressed in
  • seminiferous tubule

  • spermatid

  • esophagus

  • primary oocyte

  • lip

  • dentate gyrus of hippocampal formation granule cell

  • zygote

  • Region I of hippocampus proper

  • lacrimal gland

  • secondary oocyte
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • thiol-dependent deubiquitinase
  • peptidase activity
  • cysteine-type peptidase activity
  • NEDD8-specific protease activity
  • ubiquitin binding
  • protein binding
  • hydrolase activity
Cellular component
  • nucleus
Biological process
  • protein deubiquitination
  • protein K63-linked deubiquitination
  • protein K48-linked deubiquitination
  • proteolysis
  • protein K11-linked deubiquitination
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

78990

68149

Ensembl

ENSG00000089723
ENSG00000277276

ENSMUSG00000021203

UniProt

Q96DC9

Q9CQX0

RefSeq (mRNA)

NM_023112

NM_001177841
NM_026580

RefSeq (protein)

NP_075601

NP_001171312
NP_080856

Location (UCSC)Chr 14: 94.03 – 94.05 MbChr 12: 103.35 – 103.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin thioesterase OTUB2 is an enzyme that in humans is encoded by the OTUB2 gene.[5][6]

Otubains are deubiquitinating cysteine proteases (DUBs; see MIM 602519) that belong to the ovarian tumor (OTU) protein superfamily. Like other DUBs, otubains cleave proteins precisely at the ubiquitin (UB; see MIM 191339)-protein bond.[6]

References

  1. ^ a b c ENSG00000277276 GRCh38: Ensembl release 89: ENSG00000089723, ENSG00000277276 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021203 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Balakirev MY, Tcherniuk SO, Jaquinod M, Chroboczek J (Apr 2003). "Otubains: a new family of cysteine proteases in the ubiquitin pathway". EMBO Rep. 4 (5): 517–22. doi:10.1038/sj.embor.embor824. PMC 1319179. PMID 12704427.
  6. ^ a b "Entrez Gene: OTUB2 OTU domain, ubiquitin aldehyde binding 2".

Further reading

  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Nanao MH, Tcherniuk SO, Chroboczek J, et al. (2005). "Crystal structure of human otubain 2". EMBO Rep. 5 (8): 783–8. doi:10.1038/sj.embor.7400201. PMC 1299112. PMID 15258613.
  • Namciu SJ, Friedman RD, Marsden MD, et al. (2004). "Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1". Mamm. Genome. 15 (3): 162–78. doi:10.1007/s00335-003-2311-y. PMID 15014966. S2CID 8594824.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. Bibcode:2003Natur.421..601H. doi:10.1038/nature01348. PMID 12508121.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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  • 1tff: Structure of Otubain-2
    1tff: Structure of Otubain-2


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