ORAI2

Protein-coding gene in the species Homo sapiens
ORAI2
Identifiers
AliasesORAI2, C7orf19, CBCIP2, MEM142B, TMEM142B, ORAI calcium release-activated calcium modulator 2
External IDsOMIM: 610929; MGI: 2443195; HomoloGene: 32799; GeneCards: ORAI2; OMA:ORAI2 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for ORAI2
Genomic location for ORAI2
Band7q22.1Start102,433,106 bp[1]
End102,456,825 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for ORAI2
Genomic location for ORAI2
Band5|5 G2Start136,176,313 bp[2]
End136,199,567 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • renal medulla

  • ventral tegmental area

  • pylorus

  • superior vestibular nucleus

  • nipple

  • inferior ganglion of vagus nerve

  • superior surface of tongue

  • trigeminal ganglion

  • pericardium

  • subthalamic nucleus
Top expressed in
  • granulocyte

  • dentate gyrus

  • dentate gyrus of hippocampal formation granule cell

  • hippocampus proper

  • primary visual cortex

  • superior frontal gyrus

  • piriform cortex

  • thymus

  • olfactory tubercle

  • cerebellar cortex
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • store-operated calcium channel activity
  • protein binding
Cellular component
  • growth cone
  • integral component of membrane
  • membrane
Biological process
  • store-operated calcium entry
  • calcium ion transmembrane transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

80228

269717

Ensembl

ENSG00000160991

ENSMUSG00000039747

UniProt

Q96SN7

Q8BH10

RefSeq (mRNA)

NM_032831
NM_001126340
NM_001271818
NM_001271819

NM_178751

RefSeq (protein)

NP_001119812
NP_001258747
NP_001258748
NP_116220

NP_848866

Location (UCSC)Chr 7: 102.43 – 102.46 MbChr 5: 136.18 – 136.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein orai-2 is a protein that in humans is encoded by the ORAI2 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160991 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039747 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A (May 2006). "A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function". Nature. 441 (7090): 179–85. Bibcode:2006Natur.441..179F. doi:10.1038/nature04702. PMID 16582901. S2CID 1605392.
  6. ^ "Entrez Gene: TMEM142B transmembrane protein 142B".

Further reading

  • DeHaven WI, Smyth JT, Boyles RR, Putney JW (2007). "Calcium inhibition and calcium potentiation of Orai1, Orai2, and Orai3 calcium release-activated calcium channels". J. Biol. Chem. 282 (24): 17548–56. doi:10.1074/jbc.M611374200. PMID 17452328.
  • Mercer JC, Dehaven WI, Smyth JT, et al. (2006). "Large Store-operated Calcium Selective Currents Due to Co-expression of Orai1 or Orai2 with the Intracellular Calcium Sensor, Stim1". J. Biol. Chem. 281 (34): 24979–90. doi:10.1074/jbc.M604589200. PMC 1633822. PMID 16807233.
  • Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • <Please add first missing authors to populate metadata.> (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.


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