OR10A2

Protein-coding gene in humans
OR10A2
Identifiers
AliasesOR10A2, OR10A2P, OR11-82, OR11-86, OST363, olfactory receptor family 10 subfamily A member 2
External IDsMGI: 3030548; HomoloGene: 72055; GeneCards: OR10A2; OMA:OR10A2 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for OR10A2
Genomic location for OR10A2
Band11p15.4Start6,863,057 bp[1]
End6,874,717 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for OR10A2
Genomic location for OR10A2
Band7|7 E3Start106,670,188 bp[2]
End106,677,009 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • gonad

  • primary visual cortex

  • anterior cingulate cortex
    n/a
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • olfactory receptor activity
  • signal transducer activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

341276

259035

Ensembl

ENSG00000170790

ENSMUSG00000049674

UniProt

Q9H208

Q7TRN0

RefSeq (mRNA)

NM_001004460

NM_147033

RefSeq (protein)

NP_001004460

NP_667244

Location (UCSC)Chr 11: 6.86 – 6.87 MbChr 7: 106.67 – 106.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor family 10 subfamily A member 2 is a protein that in humans is encoded by the OR10A2 gene. [5]

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008].

Genetic differences

OR10A2 (as well as OR6A2 which is located near it on chromosome 11) has been proposed as a candidate gene responsible for the genetic portion of the variation in cilantro preference.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170790 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049674 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Olfactory receptor family 10 subfamily A member 2". Retrieved 2020-04-19.
  6. ^ Eriksson N, Wu S, Do CB, Kiefer AK, Tung JY, Mountain JL, Hinds DA, Francke U (29 November 2012). "A genetic variant near olfactory receptor genes influences cilantro preference". Flavour. 1. arXiv:1209.2096. doi:10.1186/2044-7248-1-22. S2CID 199627.

Further reading

  • v
  • t
  • e

This article incorporates text from the United States National Library of Medicine, which is in the public domain.