Kuguaglycoside

A kuguaglycoside is one of several chemical compounds (cucurbitane triterpenoid glycosides) isolated from the roots of the bitter melon vine (Momordica charantia, kǔguā in Chinese) by J.-C. Chen and others.[1]

Kuguaglycosides are glycosides of triterpene derivatives, with the cucurbitane skeleton. They are colorless solids, soluble in methanol, ethyl acetate, and butanol.[1] They include:

  • Kuguaglycoside A: 3β-hydroxy-7β-methoxycucurbita-5,24-dien-23-yl β-glucopyranoside, C
    37    H
    62    O
    8    [1]
  • Kuguaglycoside B: 3β-hydroxy-25-methoxycucurbita-5,23-dien-7β-yl β-glucopyranoside, C
    37    H
    62    O
    8    [1]
  • Kuguaglycoside C: 7β-(β-glucopyranosyloxy)-3β-hydroxycucurbita-5,23,25-trien-19-al, C
    36    H
    56    O
    8     (colorless needles)[1]
  • Kuguaglycoside D: 3β,19,23-trihydroxycucurbita-5,24-dien-7β-yl β-glucopyranoside, C
    36    H
    60    O
    9    [1]
  • Kuguaglycoside E: 23-(β-glucopyranosyloxy)-3β,19-dihydroxycucurbita-5,24-dien-7β-yl β-glucopyranoside, C
    42    H
    70    O
    14    [1]
  • Kuguaglycoside F: 23-(β-glucopyranosyloxy)-7β-methoxycucurbita-5,24-dien-3β-yl β-allopyranoside, C
    43    H
    72    O
    13    [1]
  • Kuguaglycoside G: 23-(β-glucopyranosyloxy)-3β-hydroxycucurbita-5,24-dien-7β-yl β-glucopyranoside, C
    42    H
    70    O
    13    [1]
  • Kuguaglycoside H: 23-(β-glucopyranosyl(1→2)-β-glucopyranosyl)-3β-hydroxycucurbita-5,24-dien-7β-yl β-glucopyranoside, C
    48    H
    80    O
    18     (colorless needles)[1]

Kuguaglycoside B is also found in the fruit of M. charantia.[2]

References

  1. ^ a b c d e f g h i j Jian-Chao Chen, Lu Lu, Xian-Ming Zhang, Lin Zhou, Zhong-Rong Li, and Ming-Hua Qiu (2008), "Eight New Cucurbitane Glycosides, Kuguaglycosides A–H, from the Root of Momordica charantia L.". Helvetica Chimica Acta, volume 91, issue 5, pages 920-928. doi:10.1002/hlca.200890097
  2. ^ Jie-Qing Liu, Jian-Chao Chen, Cui-Fang Wang and Ming-Hua Qiu (2009), "New Cucurbitane Triterpenoids and Steroidal Glycoside from Momordica charantia". Molecules, volume 14, pages 4804-4813 doi:10.3390/molecules14124804
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