Protein-coding gene in the species Homo sapiens
| ILKAP |
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| Identifiers |
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| Aliases | ILKAP, ILKAP2, ILKAP3, PP2C-DELTA, PPM1O, ILK associated serine/threonine phosphatase, PP2CD |
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| External IDs | MGI: 1914694; HomoloGene: 31525; GeneCards: ILKAP; OMA:ILKAP - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 2 (human)[1] |
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| | Band | 2q37.3 | Start | 238,170,402 bp[1] |
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| End | 238,203,708 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 1 (mouse)[2] |
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| | Band | 1|1 D | Start | 91,373,861 bp[2] |
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| End | 91,398,815 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - cerebellar hemisphere
- right hemisphere of cerebellum
- granulocyte
- gastric mucosa
- muscle layer of sigmoid colon
- anterior pituitary
- body of uterus
- right lobe of thyroid gland
- left lobe of thyroid gland
- tibial nerve
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| | Top expressed in | - neural layer of retina
- ventricular zone
- neural tube
- granulocyte
- epiblast
- thymus
- muscle of thigh
- right kidney
- lip
- embryo
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| | More reference expression data |
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| BioGPS |  | | More reference expression data |
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| Gene ontology |
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| Molecular function | - protein serine/threonine phosphatase activity
- protein binding
- catalytic activity
- phosphoprotein phosphatase activity
- hydrolase activity
- metal ion binding
- cation binding
| | Cellular component | - cytoplasm
- nucleus
- nucleoplasm
- cytosol
| | Biological process | - protein dephosphorylation
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 2: 238.17 – 238.2 Mb | Chr 1: 91.37 – 91.4 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Integrin-linked kinase-associated serine/threonine phosphatase 2C is an enzyme that in humans is encoded by the ILKAP gene.[5]
The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway.[5]
Interactions
ILKAP has been shown to interact with Integrin-linked kinase.[6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000132323 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026309 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: ILKAP integrin-linked kinase-associated serine/threonine phosphatase 2C".
- ^ Leung-Hagesteijn C, Mahendra A, Naruszewicz I, Hannigan GE (May 2001). "Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1". The EMBO Journal. 20 (9): 2160–70. doi:10.1093/emboj/20.9.2160. PMC 125446. PMID 11331582.
Further reading
- Tong Y, Quirion R, Shen SH (December 1998). "Cloning and characterization of a novel mammalian PP2C isozyme". The Journal of Biological Chemistry. 273 (52): 35282–90. doi:10.1074/jbc.273.52.35282. PMID 9857069.
- Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Leung-Hagesteijn C, Mahendra A, Naruszewicz I, Hannigan GE (May 2001). "Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1". The EMBO Journal. 20 (9): 2160–70. doi:10.1093/emboj/20.9.2160. PMC 125446. PMID 11331582.
- Kumar AS, Naruszewicz I, Wang P, Leung-Hagesteijn C, Hannigan GE (April 2004). "ILKAP regulates ILK signaling and inhibits anchorage-independent growth". Oncogene. 23 (19): 3454–61. doi:10.1038/sj.onc.1207473. PMID 14990992.
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
