HNRPU

HNRNPU
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZRJ
Identifiers
Aliases	HNRNPU, HNRPU, SAF-A, U21.1, hnRNP U, SAFA, HNRNPU-AS1, heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A), heterogeneous nuclear ribonucleoprotein U, HNRNPU antisense RNA 1, C1orf199, NCRNA00201, EIEE54, pp120, GRIP120, DEE54
External IDs	OMIM: 602869; MGI: 1858195; HomoloGene: 22991; GeneCards: HNRNPU; OMA:HNRNPU - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q44 Start 244,840,638 bp[1] End 244,864,560 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm ventricular zone ganglionic eminence tendon of biceps brachii caput epididymis Achilles tendon bronchial epithelial cell epithelium of colon trabecular bone corpus epididymis n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein binding telomerase RNA binding RNA binding RNA polymerase II complex binding TFIIH-class transcription factor complex binding DNA binding chromatin binding double-stranded DNA binding single-stranded DNA binding transcription corepressor activity double-stranded RNA binding single-stranded RNA binding mRNA 3'-UTR binding actin binding poly(A) binding snRNA binding poly(C) RNA binding chromatin DNA binding poly(G) binding pre-mRNA binding ribonucleoprotein complex binding protein-containing complex binding sequence-specific double-stranded DNA binding ATP binding identical protein binding sequence-specific DNA binding RNA polymerase II C-terminal domain binding promoter-specific chromatin binding RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component CRD-mediated mRNA stability complex cytoplasm catalytic step 2 spliceosome membrane nucleoplasm telomerase holoenzyme complex cytoplasmic ribonucleoprotein granule spliceosomal complex nucleus extracellular matrix nuclear chromosome cell surface nuclear matrix nuclear speck protein-containing complex RNA polymerase II transcription regulator complex inactive sex chromosome ribonucleoprotein complex kinetochore centrosome midbody mitotic spindle mitotic spindle midzone mitotic spindle microtubule chromosome, centromeric region spindle pole chromosome microtubule organizing center spindle cytoskeleton dendrite cytoplasm Biological process CRD-mediated mRNA stabilization mRNA splicing, via spliceosome RNA processing negative regulation of telomere maintenance via telomerase rhythmic process mRNA processing osteoblast differentiation RNA splicing RNA metabolic process positive regulation of gene expression circadian regulation of gene expression cardiac muscle cell development cellular response to dexamethasone stimulus negative regulation of transcription by RNA polymerase II regulation of alternative mRNA splicing, via spliceosome dosage compensation by inactivation of X chromosome negative regulation of kinase activity negative regulation of transcription elongation from RNA polymerase II promoter mRNA stabilization maintenance of protein location in nucleus cellular response to glucocorticoid stimulus RNA localization to chromatin positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity positive regulation of stem cell proliferation regulation of mitotic cell cycle positive regulation of transcription by RNA polymerase II regulation of mitotic spindle assembly regulation of chromatin organization positive regulation of attachment of mitotic spindle microtubules to kinetochore protein localization to spindle microtubule cellular response to leukemia inhibitory factor negative regulation of stem cell differentiation chromatin organization cell cycle multicellular organism development cell differentiation cell division positive regulation of brown fat cell differentiation dendritic transport of messenger ribonucleoprotein complex adaptive thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3192 51810 Ensembl ENSG00000153187 ENSMUSG00000039630 UniProt Q00839 Q5RI18 Q8VEK3 RefSeq (mRNA) NM_004501 NM_031844 NM_016805 RefSeq (protein) NP_004492 NP_114032 NP_058085 Location (UCSC) Chr 1: 244.84 – 244.86 Mb n/a PubMed search [2] [3]
Wikidata
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Heterogeneous nuclear ribonucleoprotein U is a protein that in humans is encoded by the HNRNPU gene.^[4][5]

Function

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene.^[6]

Interactions

HNRPU has been shown to interact with:

• EP300,^[7]
• GTF2F1,^[8]
• Glucocorticoid receptor,^[9] and
• NDN.^[10]

References

Further reading