HNRPH3

Protein-coding gene in humans

HNRNPH3
Identifiers
AliasesHNRNPH3, 2H9, HNRPH3, heterogeneous nuclear ribonucleoprotein H3
External IDsOMIM: 602324; MGI: 1926462; HomoloGene: 11012; GeneCards: HNRNPH3; OMA:HNRNPH3 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for HNRNPH3
Genomic location for HNRNPH3
Band10q21.3Start68,331,174 bp[1]
End68,343,193 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for HNRNPH3
Genomic location for HNRNPH3
Band10|10 B4Start63,014,664 bp[2]
End63,024,217 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tendon of biceps brachii

  • ventricular zone

  • ganglionic eminence

  • left ovary

  • right ovary

  • body of uterus

  • canal of the cervix

  • cerebellar hemisphere

  • left lobe of thyroid gland

  • right hemisphere of cerebellum
Top expressed in
  • saccule

  • otic placode

  • neural layer of retina

  • otic vesicle

  • superior cervical ganglion

  • mandibular prominence

  • maxillary prominence

  • ganglionic eminence

  • primitive streak

  • ventricular zone
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • protein binding
  • nucleic acid binding
  • RNA binding
Cellular component
  • spliceosomal complex
  • nucleus
  • nucleoplasm
Biological process
  • mRNA splicing, via spliceosome
  • mRNA processing
  • RNA processing
  • epithelial cell differentiation
  • RNA splicing
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3189

432467

Ensembl

ENSG00000096746

ENSMUSG00000020069

UniProt

P31942

n/a

RefSeq (mRNA)
NM_012207
NM_021644
NM_001322434
NM_001322436
NM_001322437

NM_001322438
NM_001322439
NM_001322440
NM_001322441
NM_001322442
NM_001322443
NM_001322444
NM_001322445
NM_001322446
NM_001322447
NM_001322448
NM_001322449
NM_001322450
NM_001322451
NM_001322452
NM_001322453

NM_001079824
NM_001347457
NM_001359260
NM_001359261

RefSeq (protein)
NP_001309363
NP_001309365
NP_001309366
NP_001309367
NP_001309368

NP_001309369
NP_001309370
NP_001309371
NP_001309372
NP_001309373
NP_001309374
NP_001309375
NP_001309376
NP_001309377
NP_001309378
NP_001309379
NP_001309380
NP_001309381
NP_001309382
NP_036339
NP_067676

n/a

Location (UCSC)Chr 10: 68.33 – 68.34 MbChr 10: 63.01 – 63.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Heterogeneous nuclear ribonucleoprotein H3 is a protein that in humans is encoded by the HNRNPH3 gene.[5][6]

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA).

These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties.

The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is localized in nuclear bodies of the nucleus. This protein is involved in the splicing process and it also participates in early heat shock-induced splicing arrest by transiently leaving the hnRNP complexes. Multiple alternative transcript variants seem to be present for this gene and some appear to have intronic regions in the mRNA. Presently, only two transcript variants are fully described.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000096746 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020069 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mahe D, Mahl P, Gattoni R, Fischer N, Mattei MG, Stevenin J, Fuchs JP (Feb 1997). "Cloning of human 2H9 heterogeneous nuclear ribonucleoproteins. Relation with splicing and early heat shock-induced splicing arrest". J Biol Chem. 272 (3): 1827–36. doi:10.1074/jbc.272.3.1827. PMID 8999868.
  6. ^ a b "Entrez Gene: HNRPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9)".

Further reading

  • Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID 1286667. S2CID 41855774.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Honoré B (2000). "The hnRNP 2H9 gene, which is involved in the splicing reaction, is a multiply spliced gene". Biochim. Biophys. Acta. 1492 (1): 108–19. doi:10.1016/s0167-4781(00)00092-0. PMID 10858537.
  • Mahé D, Fischer N, Décimo D, Fuchs JP (2000). "Spatiotemporal regulation of hnRNP M and 2H9 gene expression during mouse embryonic development". Biochim. Biophys. Acta. 1492 (2–3): 414–24. doi:10.1016/s0167-4781(00)00144-5. PMID 11004512.
  • Yagüe J, Vázquez J, López de Castro JA (2001). "A post-translational modification of nuclear proteins, N(G),N(G)-dimethyl-Arg, found in a natural HLA class I peptide ligand". Protein Sci. 9 (11): 2210–7. doi:10.1110/ps.9.11.2210. PMC 2144492. PMID 11152131.
  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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