GINS1

Protein-coding gene in the species Homo sapiens
GINS1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2E9X, 2EHO, 2Q9Q

Identifiers
AliasesGINS1, PSF1, GINS complex subunit 1, IMD55
External IDsOMIM: 610608; MGI: 1916520; HomoloGene: 44516; GeneCards: GINS1; OMA:GINS1 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for GINS1
Genomic location for GINS1
Band20p11.21Start25,391,008 bp[1]
End25,452,700 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for GINS1
Genomic location for GINS1
Band2|2 G3Start150,747,320 bp[2]
End150,773,200 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • oocyte

  • secondary oocyte

  • sperm

  • embryo

  • ventricular zone

  • right testis

  • left testis

  • ganglionic eminence

  • endothelial cell

  • trabecular bone
Top expressed in
  • medial ganglionic eminence

  • primitive streak

  • fetal liver hematopoietic progenitor cell

  • otic vesicle

  • ventricular zone

  • spermatocyte

  • tail of embryo

  • otic placode

  • abdominal wall

  • primary oocyte
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • 3'-5' DNA helicase activity
Cellular component
  • cytoplasm
  • nucleus
  • nucleoplasm
  • GINS complex
Biological process
  • DNA replication
  • DNA strand elongation involved in mitotic DNA replication
  • DNA strand elongation involved in DNA replication
  • inner cell mass cell proliferation
  • DNA duplex unwinding
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9837

69270

Ensembl

ENSG00000101003

ENSMUSG00000027454

UniProt

Q14691

Q9CZ15

RefSeq (mRNA)

NM_021067

NM_001163476
NM_027014

RefSeq (protein)

NP_066545

NP_001156948
NP_081290

Location (UCSC)Chr 20: 25.39 – 25.45 MbChr 2: 150.75 – 150.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DNA replication complex GINS protein PSF1 is a protein that in humans is encoded by the GINS1 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101003 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027454 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (Nov 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
  6. ^ Chiang PW, Wang S, Smithivas P, Song WJ, Ramamoorthy S, Hillman J, Puett S, Van Keuren ML, Crombez E, Kumar A, Glover TW, Miller DE, Tsai CH, Blackburn CC, Chen XN, Sun Z, Cheng JF, Korenberg JR, Kurnit DM (Sep 1996). "Identification and analysis of the human and murine putative chromatin structure regulator SUPT6H and Supt6h". Genomics. 34 (3): 328–33. doi:10.1006/geno.1996.0294. PMID 8786132.
  7. ^ "Entrez Gene: GINS1 GINS complex subunit 1 (Psf1 homolog)".

Further reading

  • Kamada K, Kubota Y, Arata T, et al. (2007). "Structure of the human GINS complex and its assembly and functional interface in replication initiation". Nat. Struct. Mol. Biol. 14 (5): 388–96. doi:10.1038/nsmb1231. PMID 17417653. S2CID 23124923.
  • Hayashi R, Arauchi T, Tategu M, et al. (2007). "A combined computational and experimental study on the structure-regulation relationships of putative mammalian DNA replication initiator GINS". Genomics Proteomics Bioinformatics. 4 (3): 156–64. doi:10.1016/S1672-0229(06)60028-4. PMC 5054078. PMID 17127213.
  • Ueno M, Itoh M, Kong L, et al. (2005). "PSF1 is essential for early embryogenesis in mice". Mol. Cell. Biol. 25 (23): 10528–32. doi:10.1128/MCB.25.23.10528-10532.2005. PMC 1291228. PMID 16287864.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
  • Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.
  • v
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  • 2e9x: The crystal structure of human GINS core complex
    2e9x: The crystal structure of human GINS core complex


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