Ethanolamine-O-sulfate
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Preferred IUPAC name 2-Aminoethyl hydrogen sulfate | |
Other names Aminoethyl sulfate; 2-Aminoethyl hydrogen sulphate; Sulfuric acid mono 2-aminoethyl ester; WAS-34 | |
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Abbreviations | EOS |
ChemSpider |
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ECHA InfoCard | 100.011.942 |
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CompTox Dashboard (EPA) |
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InChI
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Properties | |
Chemical formula | C2H7NO4S |
Molar mass | 141.14 g·mol−1 |
Melting point | 277 °C (531 °F; 550 K) (decomposes) |
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Hazard statements | H302, H315, H319, H335 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references |
Chemical compound
Ethanolamine-O-sulfate (EOS) is an ester of sulfuric acid and ethanolamine. EOS is a GABA transaminase inhibitor which prevents the metabolism of GABA.[2] It is used as a biochemical tool in studies involving GABA.
EOS is also a diuretic[3] and an anticonvulsant.[4]
References
- ^ 2-Aminoethyl hydrogen sulfate at Sigma-Aldrich
- ^ Gudelsky GA, Apud JA, Masotto C, Locatelli V, Cocchi D, Racagni G, Muller EE (1983). "Ethanolamine-O-sulfate enhances gamma-aminobutyric acid secretion into hypophysial portal blood and lowers serum prolactin concentrations". Neuroendocrinology. 37 (5): 397–9. doi:10.1159/000123580. PMID 6646351.
- ^ German Patent DE2345291: Diuretic aminoalkyl sulfates; Somani, Pitambar; Martin, Donald Lyons (1974)
- ^ Anlezark, Gill; Horton, Roger W.; Meldrum, Brian S.; Sawaya, M. Christina B. (1976). "Anticonvulsant action of ethanolamine-O-sulfate and di-n-propylacetate and the metabolism of γ-aminobutyric acid (GABA) in mice with audiogenic seizures". Biochemical Pharmacology. 25 (4): 413–417. doi:10.1016/0006-2952(76)90343-9. PMID 779794.
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modulators
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III