Derlin-3

Protein-coding gene in the species Homo sapiens
DERL3
Identifiers
AliasesDERL3, C22orf14, IZP6, LLN2, derlin-3, derlin 3
External IDsOMIM: 610305; MGI: 1917627; HomoloGene: 41566; GeneCards: DERL3; OMA:DERL3 - orthologs
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for DERL3
Genomic location for DERL3
Band22q11.23Start23,834,503 bp[1]
End23,839,128 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for DERL3
Genomic location for DERL3
Band10|10 C1Start75,893,413 bp[2]
End75,895,941 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • bone marrow cells

  • duodenum

  • tonsil

  • epithelium of colon

  • appendix

  • body of pancreas

  • lymph node

  • spleen

  • mucosa of transverse colon

  • rectum
Top expressed in
  • salivary gland

  • submandibular gland

  • lacrimal gland

  • parotid gland

  • zygote

  • seminal vesicula

  • primary oocyte

  • secondary oocyte

  • pyloric antrum

  • epithelium of stomach
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
Cellular component
  • integral component of membrane
  • integral component of endoplasmic reticulum membrane
  • endoplasmic reticulum
  • endoplasmic reticulum membrane
  • membrane
  • signal recognition particle receptor complex
  • signal recognition particle
Biological process
  • endoplasmic reticulum unfolded protein response
  • negative regulation of retrograde protein transport, ER to cytosol
  • protein N-linked glycosylation via asparagine
  • ubiquitin-dependent ERAD pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

91319

70377

Ensembl

ENSG00000274437
ENSG00000099958

ENSMUSG00000009092

UniProt

Q96Q80

Q9D8K3

RefSeq (mRNA)

NM_001002862
NM_001135751
NM_198440
NM_001363072

NM_024440

RefSeq (protein)

NP_001002862
NP_001129223
NP_940842
NP_001350001

NP_077760
NP_001345912
NP_001345913
NP_001345914

Location (UCSC)Chr 22: 23.83 – 23.84 MbChr 10: 75.89 – 75.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Derlin-3 is a protein that in humans is encoded by the DERL3 gene.[5][6]

See also

  • Derlin-1
  • Derlin-2

References

  1. ^ a b c ENSG00000099958 GRCh38: Ensembl release 89: ENSG00000274437, ENSG00000099958 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000009092 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lilley BN, Ploegh HL (Jun 2004). "A membrane protein required for dislocation of misfolded proteins from the ER". Nature. 429 (6994): 834–40. Bibcode:2004Natur.429..834L. doi:10.1038/nature02592. PMID 15215855. S2CID 29483256.
  6. ^ "Entrez Gene: DERL3 Der1-like domain family, member 3".

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Oda Y, Okada T, Yoshida H, et al. (2006). "Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation". J. Cell Biol. 172 (3): 383–93. doi:10.1083/jcb.200507057. PMC 2063648. PMID 16449189.
  • Wang X, Bolotin D, Chu DH, et al. (2006). "AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis". J. Cell Biol. 172 (3): 409–21. doi:10.1083/jcb.200510002. PMC 2063650. PMID 16449191.
  • Morrison JI, Lööf S, He P, Simon A (2006). "Salamander limb regeneration involves the activation of a multipotent skeletal muscle satellite cell population". J. Cell Biol. 172 (3): 433–40. doi:10.1083/jcb.200509011. PMC 2063652. PMID 16449193.


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