DNAJC14

Protein-coding gene in the species Homo sapiens
DNAJC14
Identifiers
AliasesDNAJC14, DNAJ, DRIP78, HDJ3, LIP6, DnaJ heat shock protein family (Hsp40) member C14
External IDsOMIM: 606092; MGI: 1921580; HomoloGene: 12553; GeneCards: DNAJC14; OMA:DNAJC14 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for DNAJC14
Genomic location for DNAJC14
Band12q13.2Start55,820,960 bp[1]
End55,830,824 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for DNAJC14
Genomic location for DNAJC14
Band10|10 D3Start128,639,931 bp[2]
End128,655,315 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • islet of Langerhans

  • mucosa of ileum

  • stromal cell of endometrium

  • granulocyte

  • smooth muscle tissue

  • monocyte

  • tibialis anterior muscle

  • appendix

  • rectum

  • prefrontal cortex
Top expressed in
  • lacrimal gland

  • primary oocyte

  • secondary oocyte

  • granulocyte

  • right lung lobe

  • external carotid artery

  • internal carotid artery

  • lip

  • zygote

  • tail of embryo
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • G protein-coupled receptor binding
  • dopamine receptor binding
Cellular component
  • integral component of membrane
  • endoplasmic reticulum membrane
  • membrane
  • extracellular exosome
  • endoplasmic reticulum
Biological process
  • protein transport
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

85406

74330

Ensembl

ENSG00000135392

ENSMUSG00000025354

UniProt

Q6Y2X3

Q921R4

RefSeq (mRNA)

NM_032364

NM_028873
NM_001359824
NM_001359825

RefSeq (protein)

NP_115740

NP_083149
NP_001346753
NP_001346754

Location (UCSC)Chr 12: 55.82 – 55.83 MbChr 10: 128.64 – 128.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DnaJ homolog subfamily C member 14 is a protein that in humans is encoded by the DNAJC14 gene.[5][6][7]

Interactions

DNAJC14 has been shown to interact with Dopamine receptor D1.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135392 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025354 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Bermak JC, Li M, Bullock C, Zhou QY (May 2001). "Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein". Nat Cell Biol. 3 (5): 492–8. doi:10.1038/35074561. PMID 11331877. S2CID 40809366.
  6. ^ Tchernev VT, Mansfield TA, Giot L, Kumar AM, Nandabalan K, Li Y, Mishra VS, Detter JC, Rothberg JM, Wallace MR, Southwick FS, Kingsmore SF (May 2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins". Mol Med. 8 (1): 56–64. doi:10.1007/bf03402003. PMC 2039936. PMID 11984006.
  7. ^ "Entrez Gene: DNAJC14 DnaJ (Hsp40) homolog, subfamily C, member 14".

Further reading

  • Bermak JC, Zhou QY (2004). "Accessory proteins in the biogenesis of G protein-coupled receptors". Mol. Interv. 1 (5): 282–7. PMID 14993367.
  • Leclerc PC, Auger-Messier M, Lanctot PM, et al. (2002). "A polyaromatic caveolin-binding-like motif in the cytoplasmic tail of the type 1 receptor for angiotensin II plays an important role in receptor trafficking and signaling". Endocrinology. 143 (12): 4702–10. doi:10.1210/en.2002-220679. PMID 12446598.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Chen J, Huang Y, Wu H, et al. (2003). "Molecular cloning and characterization of a novel human J-domain protein gene (HDJ3) from the fetal brain". J. Hum. Genet. 48 (5): 217–21. doi:10.1007/s10038-003-0012-8. PMID 12768437.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • v
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Chaperones/
protein folding
Heat shock proteins/
Chaperonins
Other
Protein targetingUbiquitin
(ubiquitylation)Ubiquitin-like proteins
(UBL)
SUMO protein
(SUMOylation)
  • E1 SUMO-activating enzyme
  • E2 SUMO-conjugating enzyme
Other


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