CNTNAP4

Protein-coding gene in the species Homo sapiens
CNTNAP4
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4NXQ

Identifiers
AliasesCNTNAP4, CASPR4, contactin associated protein like 4, contactin associated protein family member 4
External IDsOMIM: 610518; MGI: 2183572; HomoloGene: 24912; GeneCards: CNTNAP4; OMA:CNTNAP4 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for CNTNAP4
Genomic location for CNTNAP4
Band16q23.1Start76,277,278 bp[1]
End76,560,757 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for CNTNAP4
Genomic location for CNTNAP4
Band8|8 E1Start113,296,675 bp[2]
End113,609,349 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • C1 segment

  • corpus callosum

  • endothelial cell

  • inferior ganglion of vagus nerve

  • pons

  • substantia nigra

  • subthalamic nucleus

  • medulla oblongata

  • hypothalamus

  • cerebellar hemisphere
Top expressed in
  • substantia nigra

  • ventral tegmental area

  • pontine nuclei

  • central gray substance of midbrain

  • dorsomedial hypothalamic nucleus

  • cerebellar cortex

  • habenula

  • trigeminal ganglion

  • retinal pigment epithelium

  • lobe of cerebellum
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
Cellular component
  • integral component of membrane
  • cell junction
  • plasma membrane
  • dendrite
  • synapse
  • presynaptic membrane
  • membrane
  • GABA-ergic synapse
  • integral component of presynaptic membrane
Biological process
  • regulation of synaptic transmission, dopaminergic
  • regulation of grooming behavior
  • cell adhesion
  • regulation of synaptic transmission, GABAergic
  • regulation of synapse organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

85445

170571

Ensembl

ENSG00000152910

ENSMUSG00000031772

UniProt

Q9C0A0

Q99P47

RefSeq (mRNA)
NM_033401
NM_138994
NM_001322178
NM_001322179
NM_001322180

NM_001322181
NM_001322187
NM_001322188
NM_001322189
NM_001322190
NM_001322191

NM_130457

RefSeq (protein)
NP_001309107
NP_001309108
NP_001309109
NP_001309110
NP_001309116

NP_001309117
NP_001309118
NP_001309119
NP_001309120
NP_207837
NP_620481

NP_569724

Location (UCSC)Chr 16: 76.28 – 76.56 MbChr 8: 113.3 – 113.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Contactin-associated protein-like 4 is a protein that in humans is encoded by the CNTNAP4 gene.[5][6]

This gene product belongs to the neurexin family, members of which function in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, and thrombospondin N-terminal-like domains. Alternative splicing results in two transcript variants encoding different isoforms.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000152910 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031772 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Spiegel I, Salomon D, Erne B, Schaeren-Wiemers N, Peles E (Jul 2002). "Caspr3 and caspr4, two novel members of the caspr family are expressed in the nervous system and interact with PDZ domains". Mol Cell Neurosci. 20 (2): 283–97. doi:10.1006/mcne.2002.1110. PMID 12093160. S2CID 25024421.
  6. ^ a b "Entrez Gene: CNTNAP4 contactin associated protein-like 4".

External links

Further reading

  • Kim JM, Lee KH, Jeon YJ, et al. (2007). "Identification of genes related to Parkinson's disease using expressed sequence tags". DNA Res. 13 (6): 275–86. doi:10.1093/dnares/dsl016. PMID 17213182.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
  • Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
  • Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". Comptes Rendus de l'Académie des Sciences, Série III. 318 (2): 263–72. PMID 7757816.


  • v
  • t
  • e