Amenamevir
Chemical compound
- J05AX26 (WHO)
- In general: ℞ (Prescription only)
- N-(2,6-Dimethylphenyl)-N-[2-[4-(1,2,4-oxadiazol-3-yl)anilino]-2-oxoethyl]-1,1-dioxothiane-4-carboxamide
- 841301-32-4
- 11397521
- 11701
- 9572421
- 94X46KW4AE
- D10564
- DTXSID101027753
- Interactive image
- Cc1cccc(C)c1N(CC(=O)Nc1ccc(-c2ncon2)cc1)C(=O)C1CCS(=O)(=O)CC1
InChI
- InChI=1S/C24H26N4O5S/c1-16-4-3-5-17(2)22(16)28(24(30)19-10-12-34(31,32)13-11-19)14-21(29)26-20-8-6-18(7-9-20)23-25-15-33-27-23/h3-9,15,19H,10-14H2,1-2H3,(H,26,29)
- Key:MNHNIVNAFBSLLX-UHFFFAOYSA-N
Amenamevir (trade name Amenalief) is an antiviral drug used for the treatment of shingles (herpes zoster).
It acts as an inhibitor of the zoster virus's helicase–primase complex.[1][2] Amenamevir was approved in Japan for the treatment of shingles in 2017.[3]
See also
- Pritelivir
References
- ^ Kawashima M, Nemoto O, Honda M, Watanabe D, Nakayama J, Imafuku S, et al. (November 2017). "Amenamevir, a novel helicase-primase inhibitor, for treatment of herpes zoster: A randomized, double-blind, valaciclovir-controlled phase 3 study". The Journal of Dermatology. 44 (11): 1219–1227. doi:10.1111/1346-8138.13948. PMC 5697646. PMID 28681394.
- ^ Yajima M, Yamada H, Takemoto M, Daikoku T, Yoshida Y, Long T, et al. (March 2017). "Profile of anti-herpetic action of ASP2151 (amenamevir) as a helicase-primase inhibitor". Antiviral Research. 139: 95–101. doi:10.1016/j.antiviral.2016.12.008. PMID 28027917. S2CID 43813287.
- ^ "Maruho Receives Manufacturing and Marketing Approval for Anti-Herpes Virus Agent "Amenalief® Tab. 200mg" in Japan" (Press release). evaluategroup.com. July 3, 2017.
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Herpesvirus |
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Poxviridae |
Nucleic acid inhibitors | |
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Interferon | |
Multiple/unknown |
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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