ACSM3

Protein-coding gene in the species Homo sapiens
ACSM3
Identifiers
AliasesACSM3, SA, SAH, acyl-CoA synthetase medium-chain family member 3, acyl-CoA synthetase medium chain family member 3
External IDsOMIM: 145505; MGI: 99538; HomoloGene: 74559; GeneCards: ACSM3; OMA:ACSM3 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for ACSM3
Genomic location for ACSM3
Band16p12.3Start20,610,243 bp[1]
End20,797,581 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for ACSM3
Genomic location for ACSM3
Band7|7 F2Start119,360,146 bp[2]
End119,386,736 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left ovary

  • right ovary

  • right lobe of liver

  • left uterine tube

  • body of pancreas

  • right uterine tube

  • mucosa of transverse colon

  • body of uterus

  • human kidney

  • body of stomach
Top expressed in
  • right kidney

  • left colon

  • tunica adventitia of aorta

  • proximal tubule

  • left lobe of liver

  • human kidney

  • mucous cell of stomach

  • intercostal muscle

  • pyloric antrum

  • brown adipose tissue
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • ligase activity
  • catalytic activity
  • ATP binding
  • metal ion binding
  • fatty-acyl-CoA synthase activity
  • fatty acid ligase activity
  • butyrate-CoA ligase activity
  • molecular function
Cellular component
  • mitochondrion
  • mitochondrial matrix
  • cellular component
Biological process
  • regulation of blood pressure
  • cholesterol homeostasis
  • metabolism
  • lipid metabolism
  • fatty acid metabolic process
  • fatty acid biosynthetic process
  • acyl-CoA metabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6296

20216

Ensembl

ENSG00000005187

ENSMUSG00000030935

UniProt

Q53FZ2

Q3UNX5

RefSeq (mRNA)

NM_005622
NM_202000

NM_016870
NM_212441
NM_212442

RefSeq (protein)

NP_005613
NP_973729

NP_058566
NP_997606
NP_997607

Location (UCSC)Chr 16: 20.61 – 20.8 MbChr 7: 119.36 – 119.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Acyl-coenzyme A synthetase ACSM3, mitochondrial is an enzyme that in humans is encoded by the ACSM3 gene.[5][6][7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000005187 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030935 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nabika T, Bonnardeaux A, James M, Julier C, Jeunemaitre X, Corvol P, Lathrop M, Soubrier F (Jan 1995). "Evaluation of the SA locus in human hypertension". Hypertension. 25 (1): 6–13. doi:10.1161/01.hyp.25.1.6. PMID 7843754.
  6. ^ Iwai N, Ohmichi N, Hanai K, Nakamura Y, Kinoshita M (Mar 1994). "Human SA gene locus as a candidate locus for essential hypertension". Hypertension. 23 (3): 375–80. doi:10.1161/01.hyp.23.3.375. PMID 7907320.
  7. ^ Fujino T, Takei YA, Sone H, Ioka RX, Kamataki A, Magoori K, Takahashi S, Sakai J, Yamamoto TT (Sep 2001). "Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product". The Journal of Biological Chemistry. 276 (38): 35961–6. doi:10.1074/jbc.M106651200. PMID 11470804.
  8. ^ "Entrez Gene: ACSM3 acyl-CoA synthetase medium-chain family member 3".

External links

Further reading

  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Samani NJ, Whitmore SA, Kaiser MA, Harris J, See CG, Callen DF, Lodwick D (Mar 1994). "Chromosomal assignment of the human SA gene to 16p13.11 and demonstration of its expression in the kidney". Biochemical and Biophysical Research Communications. 199 (2): 862–8. doi:10.1006/bbrc.1994.1308. PMID 8135833.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (Sep 1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
  • Iwai N, Katsuya T, Mannami T, Higaki J, Ogihara T, Kokame K, Ogata J, Baba S (Jan 2002). "Association between SAH, an acyl-CoA synthetase gene, and hypertriglyceridemia, obesity, and hypertension". Circulation. 105 (1): 41–7. doi:10.1161/hc0102.101780. PMID 11772874.
  • Narita I, Saito N, Goto S, Shirasaki A, Morioka Y, Jin S, Omori K, Sakatsume M, Arakawa M, Gejyo F (Nov 2002). "Role of genetic polymorphism in the SA gene on the blood pressure and prognosis of renal function in patients with immunoglobulin A nephropathy". Hypertension Research. 25 (6): 831–6. doi:10.1291/hypres.25.831. PMID 12484505.
  • Benjafield AV, Iwai N, Ishikawa K, Wang WY, Morris BJ (Aug 2003). "Overweight, but not hypertension, is associated with SAH polymorphisms in Caucasians with essential hypertension". Hypertension Research. 26 (8): 591–5. doi:10.1291/hypres.26.591. PMID 14567496.
  • Telgmann R, Brand E, Nicaud V, Hagedorn C, Beining K, Schönfelder J, Brink-Spalink V, Schmidt-Petersen K, Matanis T, Vischer P, Nofer JR, Hasenkamp S, Plouin PF, Drouet L, Cambien F, Paul M, Tiret L, Brand-Herrmann SM (Mar 2007). "SAH gene variants are associated with obesity-related hypertension in Caucasians: the PEGASE Study". Journal of Hypertension. 25 (3): 557–64. doi:10.1097/HJH.0b013e3280144779. PMID 17278971. S2CID 39465138.
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