7-Methylguanosine
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Names | |
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IUPAC name 7-Methylguanosin-7-ium | |
Systematic IUPAC name 2-Amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-methyl-6-oxo-6,9-dihydro-1H-purin-7-ium | |
Other names N7-Methylguanosine; 2-Amino-1,6-dihydro-7-methyl-6-oxo-9-β-D-ribofuranosylpurinium | |
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3D model (JSmol) |
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Abbreviations | m7G; m7G |
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Properties | |
Chemical formula | C11H16N5O5 |
Molar mass | 298.279 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). ![]() ![]() ![]() Infobox references |
Chemical compound
7-Methylguanosine (m7G) is a modified purine nucleoside. It is a methylated version of guanosine and when found in human urine, it may be a biomarker of some types of cancer. In the RNAs, 7-methylguanosine have been used to study and examine the reaction evolving methylguanosine. It also plays a role in mRNA as a blocking group at its 5´-end.[1]
See also
- METTL1
- 23S rRNA (guanine2445-N2)-methyltransferase
- 16S rRNA (guanine527-N7)-methyltransferase
References
- ^ Reynaud, C; Bruno, C; Boullanger, P; Grange, J; Barbesti, S; Niveleau, A (1992). "Monitoring of urinary excretion of modified nucleosides in cancer patients using a set of six monoclonal antibodies". Cancer Letters. 61 (3): 255–62. doi:10.1016/0304-3835(92)90296-8. PMID 1739950.
External links
- Metabocard for 7-Methylguanosine (HMDB01107), Human Metabolome Database, University of Alberta
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