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1F-LSD

1F-LSD
Clinical data
Other names1-Formyl-LSD; 1-Formyl-N,N-diethyllysergamide; N,N-Diethyl-1-formyl-6-methyl-9,10-didehydroergoline-8β-carboxamide
Routes of
administration		Oral; Sublingual
Drug classSerotonergic psychedelic; Hallucinogen
ATC code
  • None
Identifiers
  • N,N-Diethyl-1-formyl-6-methyl-9,10-didehydroergoline-8β-carboxamide
Chemical and physical data
FormulaC21H25N3O2
Molar mass351.450 g·mol−1
3D model (JSmol)
  • CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C=O)CC
  • InChI=1S/C21H25N3O2/c1-4-23(5-2)21(26)15-9-17-16-7-6-8-18-20(16)14(12-24(18)13-25)10-19(17)22(3)11-15/h6-9,12-13,15,19H,4-5,10-11H2,1-3H3/t15-,19-/m1/s1
  • Key:SSEPNHFOVYUBHO-DNVCBOLYSA-N

1F-LSD, or 1-formyl-LSD, also known as 1-formyl-N,N-diethyllysergamide, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD).[1][2] It is the 1-formyl derivative of LSD.[1][2][3]

The drug is assumed to act as a prodrug of LSD.[1] It produces psychedelic effects in humans similarly to LSD.[2] Effective doses have been reported to be 100 to 150 μg orally or sublingually.[2] Very little is known about the pharmacology and properties of 1F-LSD.[1]

1F-LSD was first described in the scientific literature by 2021.[2] It first emerged as a novel designer drug online in January 2019.[1][2]

Another compound, 1‐(furan‐2‐carbonyl)‐LSD (SYN-L-005), has also been referred to as "1F-LSD".[3]

See also

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References

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  1. ^ a b c d e "1F-LSD". АИПСИН (in Russian). Retrieved 26 July 2025.
  2. ^ a b c d e f Catalani V, Arillotta D, Corkery JM, Guirguis A, Vento A, Schifano F (9 February 2021). "Identifying New/Emerging Psychoactive Substances at the Time of COVID-19; A Web-Based Approach". Frontiers in Psychiatry. 11. doi:10.3389/fpsyt.2020.632405. ISSN 1664-0640. PMC 7900492. PMID 33633599.
  3. ^ a b Brandt SD, Kavanagh PV, Gare S, Elliott SP, Stratford A, Halberstadt AL (3 December 2024). "Analytical and Pharmacological Characterization of 1‐(Furan‐2‐Carbonyl)‐LSD (1F‐LSD) and Comparison With 1‐(Thiophene‐2‐Carbonyl)‐LSD (1T‐LSD)". Drug Testing and Analysis. doi:10.1002/dta.3829. ISSN 1942-7603. PMID 39624022.
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